Immune regulation and signal tranduction

通过获得国际合作研究基金的支持，我们可以获得以下科学成果：1）Kishimoto等人揭示了细胞因子刺激后细胞内信号系统的调节机制，特别是通过成功克隆新的STAT调节模块SS 1 - 1。2）Sasazuki的小组报道了特异性TCR的意义，3）Kikutani等人通过建立敲除-CD 40-CD 40 L相互作用模型，进一步研究了CD 40-CD 40 L相互作用的免疫学意义。4）Miyazono的小组研究了通过TGF-β的信号抑制机制，他们揭示了信号分子Smad之一的重要性。5）Watanabe的小组建立了Lyn-kinase敲除小鼠，他们分析了这种敲除小鼠与新型自身免疫现象的关系。6）Okumura的小组通过使用FasL转染子建立肿瘤排斥系统，发现了新型的炎性相关排斥现象。

By getting support from the grant for international research collaboration, we could get following scientific recults.1) Kishimoto's group revealed the regulatory mechanisms of intracellular signaling system after the cytokine stimulation, especially through the success of cloning new STAT regulatory modecules SSl-1.2) Sasazuki's group reported the significance of specific TCR-peptide interaction for positive selection of thymic T cell by utilizing several types of transgenic mouse which they established.3) Kikutani's group further studied the immunological significance of CD40-CD40L interaction by establishing knock-out mouse of these molecules which naturally developes autoimmune diseases.4) Miyazono's group studied the signaling suppression mechanisms through TGF-beta and they revealed the importance of one of signaling molecules Smad.5) Watanabe's group established Lyn-kinase knock-out mouse and they analyzed this knock-out mouse associating new type of autoimmune phenomenon.6) Okumura's group found new type of inflammatory associating rejection phenomenon by establishing tumor rejection systems using FasL transfectants.