Immune regulation and signal tranduction

免疫调节和信号转导

• 批准号: 08044321
• 负责人: OKUMURA Ko
• 金额: $ 2.5万
• 依托单位: Juntendo University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08044321/
• 关键词: MHC; cytokine; signal transduction; CD40, CD40L; CD80, CD86; HSI; CD95L; IL-6

To exchange the information for the collaborative research between U.S.and Japanese molecular scientists, the symposium inviting scientists from both country was organized. Following are the main item discussed at the meeting for the study of immune regulation and the mechanisms of cell transduction associated to cytokine receptors as well as lymphocyte functioning molecules.1) The role of MHC in immune respones, especialy for early T cell differentiation.2) The functional role of cytokine (IL-6 etc) and their receptors (PBSF/SDF-1) in immune response.3) Involvement of lymphocyte functioning molecules (CD40, CD40L,CD95, CD95L,CD80, CD86) in normal as well as abnormal immune response.4) Molecular and functional analysis of signal transduction associated molecules such as HSI TRAF,Jak, Src, Stats etc.families.

为交流美日两国分子科学家之间的合作研究信息，特举办此次研讨会。本次会议主要讨论免疫调节和细胞因子受体相关的细胞转导机制以及淋巴细胞功能分子的研究。1) MHC在免疫应答中的作用，特别是在早期T细胞分化中的作用。2)细胞因子（IL-6等）及其受体（PBSF/SDF-1）在免疫应答中的作用。3)淋巴细胞功能分子（CD40、CD40L、CD95、CD95L、CD80、CD86）参与正常和异常免疫应答。4)信号转导相关分子如HSI、TRAF、Jak、Src、Stats等家族的分子和功能分析。

项目成果

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Kayagaki, N. 等人：“影响生物活性的鼠 Fas 配体的多态性。”

Mimami,M.,et al.: "STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeioid cell line." Proc.Natl.Acad.Sci.USA. 93. 3963-3966 (1996)

Mimami,M.,et al.：“STAT3 激活是 gp130 介导的骨髓细胞系终末分化和生长停滞的关键步骤。”

Fukui, Y., et al.: "Positive and negative CD4_+ thymocyte selection by a single MHC class II/peptide ligand in vivo affected by its expression level in the thymus." Immunity. (in press.).

Fukui, Y., et al.：“单个 MHC II 类/肽配体体内的阳性和阴性 CD4_ 胸腺细胞选择受其在胸腺中表达水平的影响。”

Sugamura,K.,et al.: "The interleukin 2 treceptor γ chain : its role in the multiple cytokine receptor complexes and T cell development in XDCID." Annu.Rev.Immunol.14. 179-205 (1996)

Sugamura, K., et al.：“白细胞介素 2 受体 γ 链：其在 XDCID 中多种细胞因子受体复合物和 T 细胞发育中的作用。”179-205（1996）。

Nagasawa, T., et al.: "Defects of B lymphopoiesis and bone marrow myelopoisesis in mice lacking the CXC chemokine PBSF/SDF-1" Nature. 382. 635-638 (1996)

Nagasawa, T. 等人：“缺乏 CXC 趋化因子 PBSF/SDF-1 的小鼠中 B 淋巴细胞生成和骨髓骨髓生成的缺陷”，Nature。