Theoretical Development of the CD spectroscopic Method and Application to Bio-organic Science

(1)。手性邻苯二甲酸酰胺，一种用于拆分对映体和确定醇的绝对立体化学的手性助剂。(2)。CD法测定无环二醇的绝对立体化学。2.CD激子手性方法在无环1，2-二苯甲酸酯体系中的应用CD激子手性方法与空间受阻的α-乙二醇酯交换苯甲化反应：Forsklin案例。脂肪酶催化动力学拆分环丁基甲醇及其绝对立体化学的X-射线分析3，3‘-二乙酰基-4，4’，6，6‘-四甲氧基-2，2’-联苯二酚的对映拆分和绝对立体化学。天然双黄酮类阿托异构体[Cd()362.0]-(-)4‘，4’‘，7，7“-四-O-甲基铜黄酮的全合成和绝对立体化学。CD激子手性方法在手性1，2-二胺中的应用C2v对称的2，3-萘二甲酰亚胺发色团…的应用更多(8)。2-(L-萘基)丙烷-L、2-二醇及其相关化合物的对映体拆分和绝对立体化学用手性邻苯二甲酸酰胺对2-(L-萘基)丙烷-L进行对映体拆分，得到对映体(-)-二醇，其S的绝对构型由其(-)-对溴苯甲酸酯的X射线结晶学确定。通过与(S)-(-)-二醇的化学关联，确定了()-2-甲氧基-2-(1-萘基)丙酸及其相关化合物的S绝对构型。CD激子手性法测定单功能化合物绝对立体化学的新策略CD激子手性方法已被广泛应用于各种天然产物和手性合成化合物的非经验绝对构型测定。然而，CD激子手性方法的应用仅限于具有两个或更多官能团的手性化合物，因为激子CD-Cotton效应仅在两个或更多发色团之间的相互作用中才能观察到。这是CD激子手性方法的一个弱点，因此它从未被应用于单功能手性化合物。报道了一种用CD激子手性方法测定单官能团化合物绝对构型的新方法。较少

(1). Chiral Phthalic Acid Amide, a Chiral Auxiliary Useful for Enantiomer Resolution and X-Ray Crystallographic Determination of the Absolute Stereochemistry of Alcohols.(2). A CD Method for Determination of the Absolute Stereochemistry of Acyclic Glycols. 2. Application of the CD Exciton Chirality Method to Acyclic 1,2-Dibenzoates Systems.(3). The CD Exciton Chirality Method and Benzoylation of Sterically Hindered alpha-Glycol by Trans-Esterification : Forskolin Case.(4). Lipase-Catalyzed Kinetic Resolution of Cyclobutylmethanols and Determination of Absolute Stereochemistry by X-Ray Analysis.(5). Enantioresolution and Absolute Stereochemistry of 3,3'-DiacetyI-4,4', 6,6'-tetramethoxy- 2,2'-biphenyldiol.(6). Total Synthesis and Absolute Stereochemistry of Natural Atropisomer of Biflavone, [CD(+)362.0]-(-)4', 4''', 7,7"-Tetra-O-methylcupressuflavone.(7). Application of the CD Exciton Chirality Method to Chiral 1,2-Diamines. Use of C2v-symmetrical 2,3-Naphthalenedicarboximido Chromophore … More .(8). Enantioresolution and Absolute Stereochemistry of 2-(l-Naphthyl)propane-l, 2-diol and Related Compounds. The method using chiral phthalic acid amides was applied to make the enantioresolution of 2-(l-naphthyl)propane-l, 2-diol giving enantiopure (-)-diol, the S absolute configuration of which was unambiguously determined by X-ray crystallography of its (-)-p-bromobenzoate. The S absolute configurations of (+)-2-methoxy-2-(1-naphthyl)propionic acid and related compounds were also determined by chemical correlation to (S)-(-)-diol.(9). New Strategy for Determining the Absolute Stereochemistry of Mono-Functional Compounds by the CD Exciton Chirality Method. The CD exciton chirality method has been extensively applied to various natural products and chiral synthetic compounds to determine their absolute configurations in a nonempirical manner. However, application of the CD exciton chirality method has been limited to chiral compounds with two or more functional groups, because exciton CD Cotton effects are observable only for the interaction between two or more chromophores. This has been a weak point of the CD exciton chirality method, and therefore it has never been applied to mono-functional chiral compounds. We reported a new strategy for determining the absolute configuration of mono-fucntional compounds by the CD exciton chirality method. Less