Theoretical Development of the CD spectroscopic Method and Application to Bio-organic Science

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(1). Chiral Phthalic Acid Amide, a Chiral Auxiliary Useful for Enantiomer Resolution and X-Ray Crystallographic Determination of the Absolute Stereochemistry of Alcohols.(2). A CD Method for Determination of the Absolute Stereochemistry of Acyclic Glycols. 2. Application of the CD Exciton Chirality Method to Acyclic 1,2-Dibenzoates Systems.(3). The CD Exciton Chirality Method and Benzoylation of Sterically Hindered alpha-Glycol by Trans-Esterification : Forskolin Case.(4). Lipase-Catalyzed Kinetic Resolution of Cyclobutylmethanols and Determination of Absolute Stereochemistry by X-Ray Analysis.(5). Enantioresolution and Absolute Stereochemistry of 3,3'-DiacetyI-4,4', 6,6'-tetramethoxy- 2,2'-biphenyldiol.(6). Total Synthesis and Absolute Stereochemistry of Natural Atropisomer of Biflavone, [CD(+)362.0]-(-)4', 4''', 7,7"-Tetra-O-methylcupressuflavone.(7). Application of the CD Exciton Chirality Method to Chiral 1,2-Diamines. Use of C2v-symmetrical 2,3-Naphthalenedicarboximido Chromophore … More .(8). Enantioresolution and Absolute Stereochemistry of 2-(l-Naphthyl)propane-l, 2-diol and Related Compounds. The method using chiral phthalic acid amides was applied to make the enantioresolution of 2-(l-naphthyl)propane-l, 2-diol giving enantiopure (-)-diol, the S absolute configuration of which was unambiguously determined by X-ray crystallography of its (-)-p-bromobenzoate. The S absolute configurations of (+)-2-methoxy-2-(1-naphthyl)propionic acid and related compounds were also determined by chemical correlation to (S)-(-)-diol.(9). New Strategy for Determining the Absolute Stereochemistry of Mono-Functional Compounds by the CD Exciton Chirality Method. The CD exciton chirality method has been extensively applied to various natural products and chiral synthetic compounds to determine their absolute configurations in a nonempirical manner. However, application of the CD exciton chirality method has been limited to chiral compounds with two or more functional groups, because exciton CD Cotton effects are observable only for the interaction between two or more chromophores. This has been a weak point of the CD exciton chirality method, and therefore it has never been applied to mono-functional chiral compounds. We reported a new strategy for determining the absolute configuration of mono-fucntional compounds by the CD exciton chirality method. Less