Asymmetric Automultiplication of Chiral Compounds by Asymmetric Autocatalytic Reaction

研究了2-甲基-1-(5-嘧啶)-1-丙醇(1)的不对称自催化反应。在嘧啶-5-甲醛和二异丙基锌的反应中，具有较高e.e的(S)-1作为不对称自催化合成了具有较高e.e.e的(S)-1。当(S)-1具有较低的e.e时，新生成的(S)-1具有较高的e.e。利用新形成的(S)-1分子筛作为下一步反应的不对称自催化剂，得到了E.E.(S)-1达到90%e.E.喹啉基烷醇也是一种不对称自催化，在喹啉-3-甲醛和二异丙基锌的反应中有94%的当量。

Asymmetric autocatalytic reaction of 2-methyl-1- (5-pyrimidyl) -1-propanol (1) was examined. (S) -1 with high e.e.worked as an asymmetric autocatalysis in the reaction of pyrimidine-5-carbaldehyde and diisopropylzinc to afford (S) -1 with high e.e. When (S) -1 with low e.e.was employed as an asymmetric autocatalyst, the newly formed (S) -1 had an higher e.e. By using the newly formed (S) -1 as the asymmetric autocatalyst for the next reaction, the e.e. of (S) -1 reached 90%e.e. Quinolyl alkanol is also an asymmetric autocatalysis to afford itself with 94% e.e.in the reaction of quinoline-3-carbaldehyde and diisopropylzinc.