The Origins of Chirality and Amplification in Asymmetric Autocatalysis

与生物相关的化合物，如L-氨基酸，是由其中一个对映体组成的。这种现象被称为生物同性，同性的起源引起了广泛的兴趣。不对称自催化反应，即SOAI反应，是指手性产物作为自身生成的手性催化剂的反应。研究发现，碳、氢、氧的手性同分异构体、自发绝对不对称合成、核酸碱类等非手性有机化合物形成的手性晶体是不对称自催化的手性引发剂。得到了与手性引发剂的绝对构型相对应的高对映体富集手性化合物。

Biologically related compounds such as L-amino acids are composed of one of the enantiomers. The phenomenon is called biological homochirality, and the origin of homochirality has attracted broad interest. Asymmetric autocatalysis, i.e., Soai reaction, is a reaction in which chiral product acts as a chiral catalyst for its own production. It was found that chiral isotopomers of carbon, hydrogen and oxygen, spontaneous absolute asymmetric synthesis, chiral crystals formed from achiral organic compounds such as nucleic acid base act as chiral initiators of asymmetric autocatalysis. Highly enantioenriched chiral compounds withthe corresponding absolute configurations with those of chiral initiators are obtained.