Sudies on the detoxication of lactic acid bacteria on mutagenicity of aflatoxin

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(1) Antimutagenic activities of milk cultured with five Lactobacillus strains on the mutagenicities of aflatoxins B_1, B_2 and G1 were investigated in vitro using Salmonella typhimurium TA 100 as the indicator bacteria. Cultured milk that was cultured with Lactobacillus acidophilus LA-2 strain had the highest inhibition (58.6 to 77.4%) again the mutagenicities of all the aflatoxins tested in S.typhimurium TA100 under the standard assay conditions with 8-9mix.(2) Effect of aflatoxins B_1, B_2, G_1, and G_2 on growth of glia cells was investigated by use of rats. Number of glia cells reached to ca. 1.5*10^5 cells/well after the incubation for 7 days in a well containing aflatoxin B_2, G_1or G_2, which was almost the same level to that observed in a control well. However, aflatoxin B_1 was observed to have strong inhibition to the growth of glia cells.(3) There was high percentage of binding in autoclave cells of Enterococcus faecalis FK-23 toward aflatoxins B_1, B_2, G_1, G_2.