权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

A study on the mechanism and biomarker of neurotoxicity of organic solvents.

有机溶剂神经毒性机制及生物标志物研究

基本信息

批准号：
07457104
负责人：
TAKEUCHI Yasuhiro
金额：
$ 4.86万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

项目摘要

1. Amines in the brain was investigated to clarify the effects of toluene on the central nervous system (CNS) in the rat. The amines were measured with microdialysis method. Toluene exposure increased activity of rat without dopamin increase in the striatum. The results showed that toluene might have effects on CNS through different mechanism from amphethamine and the amines might be useful biomarkers for research of neurotoxic effects of organic solvents on CNS.2. The brain of a toluene sniffer was investigated with magnetic resonance imaging (MRI) and atrophy of the brain and leukoencephalopathy were found. The similar but slighter findings of the brain was found in a worker exposed to toluene in the workplace. These results showed that the findings of the brain with MRI method might be useful biomarkers to clarify the effects of organic solvents on CNS.3. The toxicity of hexane and its metabolites on the cultivated Schwann cells was investigated and 2,5-dimethylfuran was found the most toxic among them. The results showed that in addition to 2,5-hexanedione which is well known as a main causative neurotoxicant, 2,5-dimethylfuran might be involved in neurotoxicity of hexane. 4. The available industrial neurotoxic chemicals and neurotoxic hazards due to them in Japan were investigated and proposed some preventive measures against them.

1. 为了阐明甲苯对大鼠中枢神经系统（CNS）的影响，研究了大脑中的胺。用微透析法测定胺含量。甲苯暴露增加了大鼠纹状体的活动，但多巴胺没有增加。结果表明，甲苯与安非他明可能通过不同的机制对中枢神经系统产生影响，这两种胺类物质可能是研究有机溶剂对中枢神经系统神经毒性作用的有用生物标志物。对一个甲苯嗅探员的大脑进行了磁共振成像（MRI）检查，发现大脑萎缩和脑白质病。在工作场所接触甲苯的工人的大脑中也发现了类似但更轻微的结果。这些结果表明，MRI方法的发现可能是阐明有机溶剂对中枢神经系统影响的有用生物标志物。研究了己烷及其代谢物对培养的雪旺细胞的毒性，发现其中2,5-二甲基呋喃毒性最大。结果表明，除了2,5-己二酮是已知的主要神经毒性物质外，2,5-二甲基呋喃可能参与了己烷的神经毒性作用。4. 对日本现有的工业神经毒性化学物质及其产生的神经毒性危害进行了调查，并提出了预防措施。