Surveys on reproductive toxicity of 2-bromopropane in humans

(1)对国内2-溴丙烷工厂进行调查，明确2-溴丙烷在工人体内的量效关系。对25名工人（女14名，男11名）的个人暴露水平、血液计数、女性月经状况和男性精液指数进行了检查。根据暴露水平对检查指标进行回归分析。高龄女性多见闭经或多经。当分析仅在月经正常的女性中进行时，发现血液学指标与暴露水平之间呈负相关。然而，没有发现其他指数与暴露水平有显著关联。低于10ppm未发现严重的血液学和生殖功能障碍。然而，2-溴丙烷对造血可能产生的不良影响并不能被否定。(2)考察了1-溴丙烷对健康的影响。对27名1-溴丙烷厂女工进行了神经学检查，检查了运动神经传导速度、远端潜伏期、f波传导速度和感觉神经传导速度。以25名啤酒厂女工为对照。经神经学检查，1-溴丙烷厂27名女工中有17人振动感下降。暴露组与对照组下肢运动神经传导速度无差异，但暴露组远端潜伏期较对照组明显延长（37%）。暴露组f波传导速度和感觉神经传导速度显著降低（分别为5%和15%）。个体暴露水平时间加权平均值为0.3 ~ 49.2 ppm。目前的研究表明，几十ppm的1-溴丙烷会损害下肢周围神经。

(1) 2-Bromopropane factory in China was investigated to clarify the dose-effect relationship of 2-bromopropane in workers. Twenty-five workers (female 14, male 11) were examined on their individual exposure levels, blood counts, menstruation status for females and semen indices for males.Regression analysis of examined indices was made against exposure levels. Amenorrhea or polymenorrhea was found in elder females. When the analysis was conducted just in females with normal menstruation, a negative association was found between hematological indices and exposure levels. However, no significant association was found for other indices with exposure levels. No severe disorders of hematological and reproductive function were found below 10 ppm. However, possible adverse effects of 2-bromopropane on hematopoiesis could not be disproved.(2) Health effect of 1-bromopropane was investigated. 27 female workers of 1-bromopropane factory were examined neurologically and examined for motor nerve conduction velocity, distal latency, F-wave conduction velocity and sensory nerve conduction velocity. 25 female beer plant workers were examined as the control. 17 of the 27 female workers of the 1-bromopropane factory showed a decreased sense of vibration by neurological examination. There was no difference between the exposure group and the controls in motor nerve conduction velocity in the lower limbs, but distal latency was significantly elongated in the exposure group compared with the control (37%). F-wave conduction velocity and sensory nerve conduction velocity decreased significantly in the exposure group (5% and 15%, respectively). Individual exposure levels were 0.3-49.2 ppm in time weighted average. The present study suggests that 1-bromopropane impairs peripheral nerves in lower limbs at several dozen ppm.