Surveys on reproductive toxicity of 2-bromopropane in humans

2-溴丙烷对人体生殖毒性的调查

基本信息

批准号：
10041194
负责人：
TAKEUCHI Yasuhiro
金额：
$ 2.69万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

(1) 2-Bromopropane factory in China was investigated to clarify the dose-effect relationship of 2-bromopropane in workers. Twenty-five workers (female 14, male 11) were examined on their individual exposure levels, blood counts, menstruation status for females and semen indices for males.Regression analysis of examined indices was made against exposure levels. Amenorrhea or polymenorrhea was found in elder females. When the analysis was conducted just in females with normal menstruation, a negative association was found between hematological indices and exposure levels. However, no significant association was found for other indices with exposure levels. No severe disorders of hematological and reproductive function were found below 10 ppm. However, possible adverse effects of 2-bromopropane on hematopoiesis could not be disproved.(2) Health effect of 1-bromopropane was investigated. 27 female workers of 1-bromopropane factory were examined neurologically and examined for motor nerve conduction velocity, distal latency, F-wave conduction velocity and sensory nerve conduction velocity. 25 female beer plant workers were examined as the control. 17 of the 27 female workers of the 1-bromopropane factory showed a decreased sense of vibration by neurological examination. There was no difference between the exposure group and the controls in motor nerve conduction velocity in the lower limbs, but distal latency was significantly elongated in the exposure group compared with the control (37%). F-wave conduction velocity and sensory nerve conduction velocity decreased significantly in the exposure group (5% and 15%, respectively). Individual exposure levels were 0.3-49.2 ppm in time weighted average. The present study suggests that 1-bromopropane impairs peripheral nerves in lower limbs at several dozen ppm.

（1）对中国的2-溴丙烷工厂进行了研究，以阐明2-溴丙烷在工人中的剂量效应关系。检查了25名工人（女性14，男性11）的个人暴露水平，血液计数，女性月经状况和男性精液指数。对暴露水平进行了检查指数的回归分析。在老年女性中发现了闭经或多肌酸。当分析仅在月经正常的女性中进行，在血液学指数和暴露水平之间发现负相关。但是，没有发现暴露水平的其他指数的显着关联。在10 ppm以下未发现血液学和生殖功能的严重疾病。然而，2-溴丙烷对造血的可能不良影响不可驳回。（2）研究1-溴丙烷的健康效应。对17名1-溴丙烷工厂的女工进行了神经学检查，并检查了运动神经传导速度，远端潜伏期，F波传导速度和感觉神经传导速度。将25名女啤酒植物工人视为对照。 1-溴丙烷工厂的27名女工中有17名通过神经系统检查显示出振动感的降低。下肢的暴露组与运动神经传导速度的对照之间没有差异，但是与对照组相比，暴露组的远端潜伏期显着伸长（37％）。暴露组的F波传导速度和感觉神经传导速度显着降低（分别为5％和15％）。个体暴露水平为0.3-49.2 ppm的时间加权平均水平。本研究表明，1-溴丙烷会损害下肢下肢的周围神经。