权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Surveys on reproductive toxicity of 2-bromopropane in humans

2-溴丙烷对人体生殖毒性的调查

基本信息

批准号：
10041194
负责人：
TAKEUCHI Yasuhiro
金额：
$ 2.69万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

(1) 2-Bromopropane factory in China was investigated to clarify the dose-effect relationship of 2-bromopropane in workers. Twenty-five workers (female 14, male 11) were examined on their individual exposure levels, blood counts, menstruation status for females and semen indices for males.Regression analysis of examined indices was made against exposure levels. Amenorrhea or polymenorrhea was found in elder females. When the analysis was conducted just in females with normal menstruation, a negative association was found between hematological indices and exposure levels. However, no significant association was found for other indices with exposure levels. No severe disorders of hematological and reproductive function were found below 10 ppm. However, possible adverse effects of 2-bromopropane on hematopoiesis could not be disproved.(2) Health effect of 1-bromopropane was investigated. 27 female workers of 1-bromopropane factory were examined neurologically and examined for motor nerve conduction velocity, distal latency, F-wave conduction velocity and sensory nerve conduction velocity. 25 female beer plant workers were examined as the control. 17 of the 27 female workers of the 1-bromopropane factory showed a decreased sense of vibration by neurological examination. There was no difference between the exposure group and the controls in motor nerve conduction velocity in the lower limbs, but distal latency was significantly elongated in the exposure group compared with the control (37%). F-wave conduction velocity and sensory nerve conduction velocity decreased significantly in the exposure group (5% and 15%, respectively). Individual exposure levels were 0.3-49.2 ppm in time weighted average. The present study suggests that 1-bromopropane impairs peripheral nerves in lower limbs at several dozen ppm.

(1)为阐明2-溴丙烷在工人体内的剂量-效应关系，对我国2-溴丙烷工厂进行了调查。对25名工人（女14名，男11名）进行了个人接触水平、女性血细胞计数、月经状况和男性精液指标的检查，并对检查指标与接触水平进行回归分析。老年女性闭经或月经过多。当仅对月经正常的女性进行分析时，发现血液学指标与接触水平之间存在负相关。然而，没有发现其他指数与暴露水平的显着关联。未发现低于10 ppm的血液学和生殖功能严重紊乱。然而，2-溴丙烷对造血的可能不良影响不能被反驳。(2)研究了1-溴丙烷的健康效应。本文对27名1-溴丙烷厂女工进行了神经系统检查，测定了运动神经传导速度、远端潜伏期、F波传导速度和感觉神经传导速度。25名啤酒厂女工作为对照组。1-溴丙烷厂的27名女工中有17名神经系统检查显示振动感下降。暴露组下肢运动神经传导速度与对照组无差异，但远中潜伏期较对照组显著延长（37%）。暴露组F波传导速度和感觉神经传导速度明显降低（分别为5%和15%）。按时间加权平均值计算，个人接触水平为0.3-49.2 ppm。目前的研究表明，1-溴丙烷损害周围神经在下肢在几十ppm。