Surveys on reproductive toxicity of 2-bromopropane in humans
2-溴丙烷对人体生殖毒性的调查
基本信息
- 批准号:10041194
- 负责人:
- 金额:$ 2.69万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B).
- 财政年份:1998
- 资助国家:日本
- 起止时间:1998 至 2000
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
(1) 2-Bromopropane factory in China was investigated to clarify the dose-effect relationship of 2-bromopropane in workers. Twenty-five workers (female 14, male 11) were examined on their individual exposure levels, blood counts, menstruation status for females and semen indices for males.Regression analysis of examined indices was made against exposure levels. Amenorrhea or polymenorrhea was found in elder females. When the analysis was conducted just in females with normal menstruation, a negative association was found between hematological indices and exposure levels. However, no significant association was found for other indices with exposure levels. No severe disorders of hematological and reproductive function were found below 10 ppm. However, possible adverse effects of 2-bromopropane on hematopoiesis could not be disproved.(2) Health effect of 1-bromopropane was investigated. 27 female workers of 1-bromopropane factory were examined neurologically and examined for motor nerve conduction velocity, distal latency, F-wave conduction velocity and sensory nerve conduction velocity. 25 female beer plant workers were examined as the control. 17 of the 27 female workers of the 1-bromopropane factory showed a decreased sense of vibration by neurological examination. There was no difference between the exposure group and the controls in motor nerve conduction velocity in the lower limbs, but distal latency was significantly elongated in the exposure group compared with the control (37%). F-wave conduction velocity and sensory nerve conduction velocity decreased significantly in the exposure group (5% and 15%, respectively). Individual exposure levels were 0.3-49.2 ppm in time weighted average. The present study suggests that 1-bromopropane impairs peripheral nerves in lower limbs at several dozen ppm.
(1)为阐明2-溴丙烷在工人体内的剂量-效应关系,对我国2-溴丙烷工厂进行了调查。对25名工人(女14名,男11名)进行了个人接触水平、女性血细胞计数、月经状况和男性精液指标的检查,并对检查指标与接触水平进行回归分析。老年女性闭经或月经过多。当仅对月经正常的女性进行分析时,发现血液学指标与接触水平之间存在负相关。然而,没有发现其他指数与暴露水平的显着关联。未发现低于10 ppm的血液学和生殖功能严重紊乱。然而,2-溴丙烷对造血的可能不良影响不能被反驳。(2)研究了1-溴丙烷的健康效应。本文对27名1-溴丙烷厂女工进行了神经系统检查,测定了运动神经传导速度、远端潜伏期、F波传导速度和感觉神经传导速度。25名啤酒厂女工作为对照组。1-溴丙烷厂的27名女工中有17名神经系统检查显示振动感下降。暴露组下肢运动神经传导速度与对照组无差异,但远中潜伏期较对照组显著延长(37%)。暴露组F波传导速度和感觉神经传导速度明显降低(分别为5%和15%)。按时间加权平均值计算,个人接触水平为0.3-49.2 ppm。目前的研究表明,1-溴丙烷损害周围神经在下肢在几十ppm。
项目成果
期刊论文数量(83)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Yu,Xiaozhong: "Physiologically based pharmacoki netic modeling of metabolic interactions between n-hexane and toluene in humans."Journal of Occupational Health. 40. 293-301 (1998)
余晓忠:“基于生理学的人体正己烷和甲苯之间代谢相互作用的药代动力学模型。”职业健康杂志。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Ichihara, Gaku: "Neurotoxicity of 2-bromopropane and 1-bromopropane, substitutes for chlorofluorocarbons."Peripheral Nerve. 9. 69-76 (1998)
Ichihara, Gaku:“2-溴丙烷和 1-溴丙烷的神经毒性,氯氟烃的替代品。”周围神经。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
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謝振麟: "化学物質による皮膚障害(8)職業性接触皮膚炎"医薬ジャーナル. 36. 5-13 (2000)
谢振林:“化学物质引起的皮肤病(八)职业接触性皮炎”药学杂志36.5-13(2000)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Yu X,Johanson G,et al.: "Physiologically based pharmacokinetic modeling of metabolic interactions Between n-hexane and toluene in humans." J Occup Health. 40. 293-3* (1998)
Yu X、Johanson G 等人:“基于生理学的人体正己烷和甲苯之间代谢相互作用的药代动力学模型。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Ichihara,Gaku: "1-Bromopropane, an alternative to ozone layer depleting solvents, is dose-dependently neurotoxic to rats in long-term inhalation exposure"Toxicological Sciences. 55. 116-123 (2000)
Ichihara,Gaku:“1-溴丙烷是消耗臭氧层的溶剂的替代品,对长期吸入暴露的大鼠具有剂量依赖性神经毒性”《毒理学科学》。
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- 影响因子:0
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TAKEUCHI Yasuhiro其他文献
TAKEUCHI Yasuhiro的其他文献
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{{ truncateString('TAKEUCHI Yasuhiro', 18)}}的其他基金
Mathematical Analysis on Stability and Unstable Phenomena of Immune Models
免疫模型稳定性与不稳定现象的数学分析
- 批准号:
26400211 - 财政年份:2014
- 资助金额:
$ 2.69万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Physiological and pathological involvement of FGF-23 in mineral metabolism in human
FGF-23 在人体矿物质代谢中的生理和病理作用
- 批准号:
17590972 - 财政年份:2005
- 资助金额:
$ 2.69万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Regulation by adipocytokines of bone metabolism
脂肪细胞因子对骨代谢的调节
- 批准号:
15590970 - 财政年份:2003
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$ 2.69万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Role of bone marrow adipogenesis for bone formation and its abnormality in senile osteoporosis
骨髓脂肪生成对骨形成的作用及其异常在老年骨质疏松中的作用
- 批准号:
13671150 - 财政年份:2001
- 资助金额:
$ 2.69万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Synthetic Study on Dynamical Systems in Mathematical Biology
数学生物学中动力系统的综合研究
- 批准号:
13304006 - 财政年份:2001
- 资助金额:
$ 2.69万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Cell-matrix interaction in the regulation of bone metabolism and its disorder in involutional osteoporosis
细胞-基质相互作用在骨代谢调控中的作用及其在退化性骨质疏松症中的紊乱
- 批准号:
11671081 - 财政年份:1999
- 资助金额:
$ 2.69万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Mechanistic studies on reproductive toxicity and neurotoxicity of alternatives to chlorofluorocarbons and their risk assessment
氯氟烃替代品生殖毒性和神经毒性的机理研究及风险评估
- 批准号:
10470106 - 财政年份:1998
- 资助金额:
$ 2.69万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
Cell-matrix interaction in osteoblastic differentiation and its disorder in involutional osteoporosis
退化性骨质疏松症中成骨细胞分化及其紊乱中的细胞-基质相互作用
- 批准号:
09671031 - 财政年份:1997
- 资助金额:
$ 2.69万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Regulation of osteoblastic differentiation and its implication in involutional osteoporosis
成骨细胞分化的调控及其在退化性骨质疏松症中的意义
- 批准号:
07671111 - 财政年份:1995
- 资助金额:
$ 2.69万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A study on the mechanism and biomarker of neurotoxicity of organic solvents.
有机溶剂神经毒性机制及生物标志物研究
- 批准号:
07457104 - 财政年份:1995
- 资助金额:
$ 2.69万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
相似海外基金
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