Mechanistic studies on reproductive toxicity and neurotoxicity of alternatives to chlorofluorocarbons and their risk assessment
氯氟烃替代品生殖毒性和神经毒性的机理研究及风险评估
基本信息
- 批准号:10470106
- 负责人:
- 金额:$ 9.66万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B).
- 财政年份:1998
- 资助国家:日本
- 起止时间:1998 至 2000
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
(1) Study on female reproductive toxicity of 2-bromopropane.Experiments using Wistar female rats revealed that disruption of ovary function was due to the destruction through apoptosis of primordial follicle and its oocyte.(2) Study on male reproductive toxicity of 2-bromopropane.The experiments using Wistar male rats revealed the primary adverse effect on spermatogonia and secondary apoptosis of spermatocyte. Decrease in Bcl-2 and increase in Bax were thought to induce primary apoptosis of spermatogonia, and the increase in Fas might induce secondary apoptosis of spermatocyte.(3) Study on neurotoxicity and reproductive toxicity of 1-bromopropane.A twelve-weeks study using Wistar male rats revealed that 1-bromopropane is dose-dependently neurotoxic and disrupts spermiation at the final step of spermatogenesis. In addition, 1-bromopropane modified SH-base in brain and decreased creatine kinase activity.(4) Study on dose-effect relationship in bromopropane factory workers.The investigation of 2-bromopropane factory did not show so severe disruption of reproductive and hematopoietic function as seen in the Korean cases. However, the possibility of adverse effects on hematopoiesis could not be disproved. The investigation of the 1-bromopropane factory showed that 1-bromopropane might impair peripheral nerves in humans at several dozen ppm.
(1) 2-溴丙烷雌性生殖毒性研究。Wistar雌性大鼠的实验表明,卵巢功能的破坏是由于原始卵泡及其卵母细胞的凋亡破坏所致。(2) 2-溴丙烷的雄性生殖毒性研究。以Wistar雄性大鼠为实验对象,发现其对精原细胞有主要不良影响,对精母细胞有继发性凋亡作用。Bcl-2的降低和Bax的升高可诱导精原细胞的原发性凋亡,Fas的升高可诱导精母细胞的继发性凋亡。(3) 1-溴丙烷的神经毒性和生殖毒性研究。一项为期12周的Wistar雄性大鼠研究表明,1-溴丙烷具有剂量依赖性神经毒性,并在精子发生的最后一步破坏精子。此外,1-溴丙烷修饰脑sh碱基,降低肌酸激酶活性。(4)溴丙烷工厂工人的量效关系研究。在对2-溴丙烷工厂的调查中,没有发现像韩国病例那样严重的生殖和造血功能破坏。然而,对造血产生不良影响的可能性不能被否定。对1-溴丙烷工厂的调查表明,几十ppm的1-溴丙烷可能损害人体周围神经。
项目成果
期刊论文数量(168)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Ichihara, Gaku: "Urinary 2,5-hexanedione increased with potentiation of neurotoxicity in chronic co-exposure to n-hexane and methyl ethyl ketone."International Archives of Occupational and Environmental Health. 71. 100-104 (1998)
Ichihara, Gaku:“长期同时接触正己烷和甲基乙基酮时,尿中 2,5-己二酮会随着神经毒性的增强而增加。”国际职业与环境健康档案。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Yu X,Ichihara G,Kitoh J et al: "Effect of inhalation exposure to 2-bromopropane on the nervous system in rats."Toxicology. 135. 87-93 (1999)
Yu X,Ichihara G,Kitoh J 等人:“吸入暴露于 2-溴丙烷对大鼠神经系统的影响。”毒理学。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
市原学: "産業化学物質の生殖毒性"Eco Industry. 4. 25-32 (1999)
Manabu Ichihara:“工业化学品的生殖毒性”Eco Industry 4. 25-32 (1999)。
- DOI:
- 发表时间:
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- 影响因子:0
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Xie, Zhenlin: "Skin impairment by chemicals, contact dermatitis."Iyaku Journal. 36. 5-13 (2000)
谢振林:“化学物质损伤皮肤,接触性皮炎。”医药杂志。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Takuchi, Yasuhiro: "Reproductive toxicity and fetotoxicity. Toxicology-fundamental, clinical and social medicine"Asakura Shoten, (in press).
Takuchi, Yasuhiro:“生殖毒性和胎儿毒性。毒理学-基础、临床和社会医学”Asakura Shoten,(出版中)。
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- 影响因子:0
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TAKEUCHI Yasuhiro其他文献
TAKEUCHI Yasuhiro的其他文献
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{{ truncateString('TAKEUCHI Yasuhiro', 18)}}的其他基金
Mathematical Analysis on Stability and Unstable Phenomena of Immune Models
免疫模型稳定性与不稳定现象的数学分析
- 批准号:
26400211 - 财政年份:2014
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Physiological and pathological involvement of FGF-23 in mineral metabolism in human
FGF-23 在人体矿物质代谢中的生理和病理作用
- 批准号:
17590972 - 财政年份:2005
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Regulation by adipocytokines of bone metabolism
脂肪细胞因子对骨代谢的调节
- 批准号:
15590970 - 财政年份:2003
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Role of bone marrow adipogenesis for bone formation and its abnormality in senile osteoporosis
骨髓脂肪生成对骨形成的作用及其异常在老年骨质疏松中的作用
- 批准号:
13671150 - 财政年份:2001
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Synthetic Study on Dynamical Systems in Mathematical Biology
数学生物学中动力系统的综合研究
- 批准号:
13304006 - 财政年份:2001
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Cell-matrix interaction in the regulation of bone metabolism and its disorder in involutional osteoporosis
细胞-基质相互作用在骨代谢调控中的作用及其在退化性骨质疏松症中的紊乱
- 批准号:
11671081 - 财政年份:1999
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Surveys on reproductive toxicity of 2-bromopropane in humans
2-溴丙烷对人体生殖毒性的调查
- 批准号:
10041194 - 财政年份:1998
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
Cell-matrix interaction in osteoblastic differentiation and its disorder in involutional osteoporosis
退化性骨质疏松症中成骨细胞分化及其紊乱中的细胞-基质相互作用
- 批准号:
09671031 - 财政年份:1997
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Regulation of osteoblastic differentiation and its implication in involutional osteoporosis
成骨细胞分化的调控及其在退化性骨质疏松症中的意义
- 批准号:
07671111 - 财政年份:1995
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A study on the mechanism and biomarker of neurotoxicity of organic solvents.
有机溶剂神经毒性机制及生物标志物研究
- 批准号:
07457104 - 财政年份:1995
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
相似海外基金
Investigation on neurodegenerative effect of 1-bromopropane using new biomarkers
使用新生物标志物研究 1-溴丙烷的神经退行性作用
- 批准号:
24406018 - 财政年份:2012
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Investigation on toxicity of 1-bromopropane to central nervous system and hematopoetic function in humans
1-溴丙烷对人体中枢神经系统和造血功能的毒性研究
- 批准号:
21406017 - 财政年份:2009
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Study on dose-dependency of the central nervous system toxicity of 1-bromopropane in humans
1-溴丙烷对人体中枢神经系统毒性的剂量依赖性研究
- 批准号:
17406017 - 财政年份:2005
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Brain slice techniques as neurotoxicity tests for 1-bromopropane
脑切片技术作为 1-溴丙烷的神经毒性测试
- 批准号:
12680556 - 财政年份:2000
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Study on mechanism of reproductive toxicity and neurotoxicity of 1-bromopropane, a new alternative to chlorofluorocarbons
氯氟烃新替代品1-溴丙烷生殖毒性和神经毒性机制研究
- 批准号:
11670367 - 财政年份:1999
- 资助金额:
$ 9.66万 - 项目类别:
Grant-in-Aid for Scientific Research (C)