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Identification of genes relevant to the development of cardiac hypertrophy.

鉴定与心脏肥大发展相关的基因。

基本信息

批准号：
07457169
负责人：
IWAI Naoharu
金额：
$ 4.42万
依托单位：
Shiga University of Medical Sciences
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457169/
关键词：
renin angiotensin system hypertrophy hypertension molecular genetics レニン遺伝学肥大

项目摘要

1. Tissue renin-angiotensin system and cardiac hypertrophy. We evaluated expression of every component of renin angiotensin system in rat hypertrophied heart induced by aorto-caval shunt. We observed the importance of angiotensin-converting enzyme expressed in the ventricles in the development of hypertrophy in this model. We found that renin was expressed in rat macrophage/monocyte cells infiltraing necrotic myocardium induced by isoproterenol administration. This findning suggests that macrophage may be a source of tissue renin in various pathological conditions.2. Identification of new genes relevant to the development of cardiac hypertrophy by differential screening. We found that type II tissue transglutaminase was up-regulated in hypertrophied heart. This enzyme has been known to activate latent TGF-beta, which has potent effects on cardiac development.3. Genetic approach to the identification of new genes relevant to the development of cardiac hypertrophy. We have found that loci in the rat chromosome 1,2 and 8 has significant effects on heart/body weight ratio in F2 population derived from SHR and WKY.The effects of the loci in chromosome 2 and 8 seem to be through the effecs on blood pressure, and the effects of the chromosome 1 locus seem to be through the effects on renal function.

1.组织肾素-血管紧张素系统与心肌肥厚。本研究观察了大鼠肥厚心脏中肾素-血管紧张素系统各组分的表达。我们观察到的重要性，血管紧张素转换酶表达的心室肥大的发展，在这个模型中。我们发现，肾素表达在大鼠巨噬细胞/单核细胞浸润坏死的心肌异丙肾上腺素管理诱导。这一发现提示巨噬细胞可能是各种病理状态下组织肾素的来源.通过差异筛选鉴定与心肌肥厚发生相关的新基因。我们发现，II型组织转氨酶在肥厚的心脏上调。已知这种酶可以激活潜在的TGF-β，对心脏发育有潜在的影响。用遗传学方法鉴定与心脏肥大发生相关的新基因。我们发现，大鼠1、2、8号染色体上的基因座对SHR和WKY的F_2群体的心体重比有显著影响，其中2、8号染色体上的基因座的影响可能是通过对血压的影响，而1号染色体上的基因座的影响可能是通过对肾功能的影响。