Genetics of Essential Hypertension.

我们发现，血管紧张素转换酶基因的DD型和纤溶酶原激活物抑制物-1基因的DD型与急性冠脉综合征的快速进展相关。由于单个基因对高血压的发生的贡献似乎很小，因此需要大量的受试者来明确一个基因是否真的对高血压起作用。利用5000名受试者组成的大队列，我们发现前列环素合成酶基因是导致日本人高血压的基因之一。我们通过建立同源基因大鼠来确定影响血压或肾血流动力学功能的基因座。通过使用这些数据的比较图谱，我们可能能够找到几个与人类原发性高血压有关的候选基因。

We have found that DD genotype of the angiotensin converting enzyme gene and DD genotype of the plasminogen activator inhibitor-1 gene are associated with rapid progression to acute coronary syndromes.Since contribution of a single gene to the genesis of essential hypertension appears to be small, a large number of subjects is necessary to clearly determine whether a gene really contributes to hypertension. Using a large cohort consisted of 5000 subjects, we have found that the prostacyclin synthase gene is one of the genes contributing to hypertension in Japanese.We have identified loci that influence blood pressure or renal hemodynamic functions by establishing congenic rats. From comparative mapping using these data, we may be able to find out several candidate genes contributing to human essential hypertension.