Assessment of plasma miRNA as biomarkers for various diseases

血浆miRNAs对于识别坏死性细胞非常有用，因为miRNA的表达模式是细胞特有的。基于这一概念，我们确定了血浆miR-499、miR-124、miR-210和miR-126以及miR-216a和216b分别可作为心肌梗塞、脑梗塞、充血性心力衰竭和急性胰腺炎的生物标志物。此外，通过肌肉特异性miRNAs的表达模式，即miR-1、133a、133b、145和499，可以区分平滑肌细胞、心肌细胞和骨骼肌细胞。

Plasma miRNAs are very useful to identify necrotizing cells, since miRNA expression patterns are cell-specific. Based on this concept, we confirmed that plasma miR-499, miR-124, miR-210 and miR-126, and miR-216a and 216b, were useful as biomarkers for miocardial infarction, cerebral infarction, congestive heart failure, and acute panceratitis, respectively. Moreover, smooth muscle cells, cardiomyocytes, and skeletal muscle cells could be discriminated by expression patterns of muscle specific miRNAs, namely miR-1, 133a, 133b, 145, and 499.