权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Studies for High performance and Practical Use of Neutral Carrier-Type Ion Sensors Based on Silicone-Rubber Membranes

基于硅橡胶膜的中性载体型离子传感器的高性能及实用化研究

基本信息

批准号：
07555569
负责人：
KIMURA Keiichi
金额：
$ 4.93万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07555569/
关键词：
Ion Sensor Neutral Carrier Sensing Membrane Silicone Rubber Sol-Gel Derived Glass Practical Use 生体適合性

项目摘要

The aim of this work is to study for high performance and practical use of neutral-carrier-type ion sensors based on silicone-rubber membrane and sol-gel-derived membranes. The ion sensors studied here were ion-sensitive field-effect transistors (ISFET) and ion-selective electrodes (ISE). Calix [4] arene ionophores were mainly employed here as the sodium neutral carriers. The research results are as follows.1) Calix [4] arene ionophores incorporating structural unsymmetry and oligo (siloxane) group have been designed to obtain highly dispersible calixarene ionophore in silicone rubber.2) Sodium neutral carriers such as calix [4] arene ionophores have been successfully immobilized to silicone rubber membranes by covalent bonding, in order to attain highly durable, biocompatible neutral-carrier-based sensing membranes for ion-selectrodes.3) Oligo (dimethylsiloxane) derivatives carrying calixarene moiety have been synthesized to alleviate some drawbacks for the silicone-rubber membranes modified chemically with calixarene moiety.4) Sol-gel-derived membranes encapsulating a conventional neutral carrier such as valinomycin and bis (12-crown-4) have been designed as organic-inorganic hybrid ion-sensing membranes.5) Chemical modification of sol-gel-derived membranes with alkoxysilylated neutral carriers were attrmpted aiming at modification of glass membranes with neutral carriers.6) Any of the neutral carrier-type sodium ion sensors studied here showed high performance in sensor property, durability, and biocompatibility. Also, they have been sucessfully applied to sodium assay in human body fluid as sera and urine.

这项工作的目的是研究基于硅橡胶膜和溶胶凝胶衍生膜的中性载体型离子传感器的高性能和实用性。这里研究的离子传感器是离子敏感场效应晶体管（ISFET）和离子选择电极（ISE）。这里主要采用杯[4]芳烃离子载体作为钠中性载体。研究结果如下：1）设计了结合结构不对称性和低聚（硅氧烷）基团的杯[4]芳烃离子载体，以获得在硅橡胶中高度分散的杯芳烃离子载体。2）通过共价键合将杯[4]芳烃离子载体等钠中性载体成功固定在硅橡胶膜上，以获得高分散性。用于离子电极的耐用、生物相容性中性载体传感膜。3) 合成了携带杯芳烃部分的寡聚（二甲基硅氧烷）衍生物，以减轻用杯芳烃部分化学改性的硅橡胶膜的一些缺点。4) 封装传统中性载体的溶胶-凝胶衍生膜，例如缬氨霉素和双（12-冠-4）已被设计为有机-无机混合离子传感膜。5）尝试用烷氧基甲硅烷基化中性载体对溶胶-凝胶衍生的膜进行化学修饰，旨在用中性载体修饰玻璃膜。6）这里研究的任何中性载体型钠离子传感器都显示出高性能的传感器性能、耐久性和生物相容性。此外，它们已成功应用于血清和尿液等人体体液中的钠测定。