DRUG DELIVERY SYSTEM BY THE CONTROL OF BLOOD FLOW DISTRIBUTION USING ARTIFICIAL CIRCULATION WITH OSCILLATED BLOOD FLOW

通过使用具有振荡血流的人工循环来控制血流分布的药物输送系统

• 批准号: 07557309
• 负责人: NITTA Shin-ichi
• 金额: $ 4.29万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557309/
• 关键词: Arterial impedance; Physiological resonance; Oscillated blood flow; Liner actuator; Blood flow distribution; Drug delivery system; Left ventricular assistance; 高周波振動流; 振動流ポンプ; 血管インピーダンス; 生理的共振現象; 体血流分布

High frequency oscillated blood flow is a typical sine-wave blood flow within 10-40 Hz. It has a higher driving frequency compared with the natural heart beats. Oscillated blood flow may be useful for the new type drug delivery system from its unique driving effects. It may be possible to control the blood flow distribution by the control of driving frequency of oscillated blood flow. In this study, hemodynamic parameters were measured and estimated during artificial circulation using oscillated blood flow. Systemic vascular resistance were decreased by the start of vibrating flow pump. It may show the oscillatory effect for vascular tension by the artificial circulation using oscillated blood flow. Left common carotid arterial blood flow rate were increased by the change of driving frequency without the no change of pump output rate. The arterial impedance were estimated in this study. The branch, curve and stenosis are the major origin of reflect wave, and these points are important for the arterial impedance study. Each organ may have the suitable frequency from its physical characteristics, input impedance study may clear these characters. Blood flow distribution may be controlled by the driving frequency of oscillated blood flow, if we can make the suitable driving frequency for the target organ. The appropriate frequency driving for the target organ may generate the physiological resonance. The artificial circulation using high frequency oscillated blood flow may become the one of the new type drug delivery system.

高频振荡血流是一种典型的10-40赫兹的正弦波血流。与自然的心跳相比，它的驱动频率更高。由于其独特的驱动作用，血流振荡可能对新型给药系统有一定的应用价值。通过控制振荡血流的驱动频率来控制血流分布是可能的。在这项研究中，测量和估计血流动力学参数在人工循环中使用振荡血流。振动泵启动后，体循环阻力明显降低。它可以通过利用振荡血流的人工循环来显示血管张力的振荡效应。随着驱动频率的改变，左颈总动脉血流速度增加，而泵输出量不变。在本研究中对动脉阻抗进行了估计。分支、曲线和狭窄是反射波的主要来源，这些点对动脉阻抗的研究具有重要意义。每个器官从其物理特性可以有合适的频率，输入阻抗研究可以明确这些特征。如果能为靶器官制定合适的驱动频率，就可以通过振荡血流的驱动频率来控制血流的分布。对靶器官进行适当的频率驱动可以产生生理共振。利用高频振荡血流的人工循环有可能成为一种新型的药物输送系统。

项目成果

T.Yambe, K.Shizuka, K.Izutsu, T.Sonobe, S.Naganuma, S.Kobayashi, S.Nanka, H.Hashimoto, M.Yoshizawa, K.Tabayashi, H.Takeda, S.Nitta.: "Pulmonary arterial impedance analysis by the use of the oscillated assist flow." Artificial Organs. 21 (7). 751-754 (1997

T.Yambe、K.Shizuka、K.Izutsu、T.Sonobe、S.Naganuma、S.Kobayashi、S.Nanka、H.Hashimoto、M.Yoshizawa、K.Tabayashi、H.Takeda、S.Nitta：“

T.Yambe, S.Nitta, et al: "Pulmonary arterial impedance analysis by the use of the oscillated assist flow" Artificial Organs. 21,No.7. 751-754 (1997)

T.Yambe、S.Nitta 等人：“使用振荡辅助流进行肺动脉阻抗分析”人工器官。

S.Kobayashi, S.Nitta, et al.: "Hemolysis test of disposable type vibrating flow pump" Artificial Organs. 21,No.7. 691-693 (1997)

S.Kobayashi，S.Nitta，等人：“一次性型振动流泵溶血试验”人工器官。

Tomoyuki Yambe: "Fractal Dimension Analysis of the Oscillated Blood Flow with a Vibrating Flow Pump" Artificial Organs. 19(7). 729-733 (1995)

Tomoyuki Yambe：“使用振动流泵对振荡血流进行分形维数分析”人造器官。

S.Naganuma, S.Nitta, et al.: "Development of a novel centrifugal pump:Magnetic rotary pump" Artificial Organs. 21,No.7. 746-750 (1997)

S.Naganuma、S.Nitta 等人：“新型离心泵的开发：磁力旋转泵”人工器官。