ANALYSIS OF TEMPERATURE CHARACTERISTIC OF SYSTOLE IN HIBERNATOR WITH ULTRASONIC TOMOGRAPHY

超声断层扫描分析冬眠器心搏温度特性

• 批准号: 07670086
• 负责人: OHWATARI Nobu
• 金额: $ 1.47万
• 依托单位: NAGASAKI UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670086/
• 关键词: HIBERNATOR; CARDIO FUNCTION; ACUTE COLD EXPOSURE; ULTRASONIC TOMOGRAPH; HYPOTHERMIA; 冬眠動物,; 心収縮特性; 超音波画像; 寒冷耐性; 温度特性; 寒冷ふるえ熱産生; 非ふるえ熱産生

In this study, I examined temperature characteristic of cardiac function with ultrasonic tomograph by B- and M-modes under a course of hypothermia at 8ﾟC caused by acute cold exposure hibernator (Syrian hamster). I compared it with experimental findings of non-hibernator (Wistar rat) as control group.In electrocardiography (ECG), complete atrioventricular block was observed at abdominal temperature (Tab) of 19ﾟC with non-hibernator, but atrio-ventricular block of the first stage that P-Q interval got longer at 10ﾟC was recognized in hibernator. Furthermore, Tab was 18.11 <plus-minus> 0.83ﾟC in non-hibernator, then ECG disappeared. But the phenomenon wasn't observed to depressed Tab of 7.22 <plus-minus> 0.31ﾟC in hibernator. Movement of myocardium of left ventricle became slow when became less than 21.8ﾟC with non-hibernator in ultrasonic tomography of heart stroke. Speed of mitral valve also observed slowly, so degradation of cardiac output was suggested. On the other hand, similar development was found by 9.8ﾟC in hibernator. As examination subject after now, it couldn't measure a clear ultrasonic tomography by shivering of cold exposure early stIn non-hibernation, cardiac function of hibernator was maintained under hypothermia, the significant cold tolerance was provided as well as in hibernation.

在这项研究中，我在急性冷暴露冬眠者（叙利亚仓鼠）引起的8°C低温过程中，通过B型和M型超声波断层扫描检查了心脏功能的温度特征。将其与作为对照组的非冬眠者（Wistar大鼠）的实验结果进行比较。在心电图（ECG）中，非冬眠者在腹温（Tab）为19°C时观察到完全性房室传导阻滞，但在冬眠者中观察到P-Q间隔在10°C变长的第一阶段房室传导阻滞。此外，非冬眠者Tab为18.11<正负>0.83°C，然后心电图消失。但在冬眠条件下，Tab 7.22±0.31℃时未观察到这种现象。心脏病超声断层扫描中非冬眠状态下，当温度低于21.8℃时，左心室心肌运动变慢。还观察到二尖瓣速度缓慢，因此表明心输出量下降。另一方面，9.8℃在冬眠器中也发现了类似的发展。作为今后的检查对象，在非冬眠初期的受冷寒颤无法测量出清晰的超声波断层扫描，冬眠者的心脏功能在低温下得以维持，与冬眠时一样具有显着的耐冷能力。

项目成果

Nobu Ohwatari: "A new approach to analysis of human sweating." Experientia. 52. 131-135 (1996)

Nobu Ohwatari：“一种分析人类出汗的新方法。”

Nobu Ohwatari: "A field study of telemetry-recording of the body temperature in wild Mongolian pikas." Trop Med. 37(3). 93-98 (1995)

Nobu Ohwatari：“对野生蒙古鼠兔体温遥测记录的实地研究。”

Ohwatari N: "Body temperature and metabolism." Ed by Nagasaka T and Milton AS,IPEC inc.,Tokyo, 376 (1995)

Ohwatari N：“体温和新陈代谢。”

Pleschka K,Schnecko A,Lemmer B,Ohwatari N and Ntirnberger F: "In vitro stimulation of adenylyl cyclase in the hippocampus, cortex and cerebellum of euthermic and hibernating hamsters" In Adaptations to the Cold, Ed Geiser F,Hulbert A J and Nicol S C,Unive

Pleschka K、Schnecko A、Lemmer B、Ohwatari N 和 Ntirnberger F：“体外刺激恒温和冬眠仓鼠海马、皮质和小脑中的腺苷酸环化酶”，《适应寒冷》，Ed Geiser F、Hulbert A J 和 Nicol SC

Nobu Ohwatari: "Behavioral thermoregulation of Pika-Thermal insulation of fur and skin-" Parmacolgy of Thermoregulation. 10(in press). (1996)

Nobu Ohwatari：“鼠兔的行为温度调节-皮毛和皮肤的隔热-”温度调节的Parmacolgy。