Deterioration action by solar ultraviolet rays exposure on infection and symptom of Schistosomiasis and in symptom, and evaluation it

太阳紫外线照射对血吸虫病感染及症状的恶化作用及其评价

基本信息

批准号：
13680630
负责人：
OHWATARI Nobu
金额：
$ 2.37万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

On this study, we experimented about a change of immunological ability induced by exposure of solar ultraviolet rays and an influence of the change on a sick infection, and examine whether ultraviolet rays participates in sick infection, or not. We used cercariae of Schistosoma mansoni for infectious experiments.In results of artificial ultraviolet rays (UV-B) irradiation with 400 J/m^2 of UV-B, Schistosomiasis became worsen by UV-B irradiation, because both cercariae invaded into skin tissue and adult warm recovered increased significantly as comparison with non-irradiation group (p<0.01).In solar light exposure contained with 400 J/m^2 of UV-B, there was not significant difference in numbers of each cercariae invaded into skin tissue and adult warm recovered as comparison with non-exposure group (control group).In solar light irradiation contained with 800 J/m^2 of UV-B, the body temperature of mice increased by infrared rays, so we used with ice pack for restrain it by behavior ther … More mo-regulation. On immunity, CD4/CD8 in mice decreased to the significant minimum value in 7 days after solar light exposure, but it recovered in after 2 weeks. The cercariae invaded increased significantly compared with control group (p<0.05). However, it was not significant difference in adult warm recovered.Further more in solar light exposure with 1600 J/m^2, we stopped infection experiments because damages induced by sunstroke in mice.As considerations, the effective radiation dose of UV-B in solar light was high compared with artificial UV-B. It is guessed that continuous spectrum of solar light need much dose to get equal effects compared with discontinuity spectra of artificial UV-B.Exposure to solar light at 800 J/m^2 of UV-B caused depression of immunity, and it enhanced cercariae to invade into skin tissue. These suggest that UV-B in solar light becomes worsen in infection of Schistosomiasis. Furthermore, wemust investigate for human health about growing up of cercariae in the body with solar light exposure through experiments over 800 J/m^2 with temperature control equipment. Less

在这项研究中，我们试验了暴露于太阳能紫外线射线引起的免疫能力的变化以及对病人感染的影响的影响，并检查紫外线是否参与病态感染。我们使用曼氏菌的核心进行感染实验。在人造紫外线射线（UV-B）辐射的结果中，uv-b的400 j/m^2，uv-b辐射不知名，因为两者都在与皮肤组织和成人型不适合<-ir-ir-ir-ir-ir-ir-ir-ir-iractiation contecuence non-efformiation corcariae corcariae cercariae cercariae cercariae cercaria eventiation non-eforriation（priractiation）（priractiation）（priractiation）。包含400 j/m^2的UV-B，每种尾car虫的数量没有显着差异，因为与非暴露组（对照组）进行了比较，在皮肤组织中恢复了。在免疫力下，小鼠的CD4/CD8在太阳光线暴露后的7天内降至显着的最小值，但在2周后恢复。与对照组相比，cercariae被显着入侵（p <0.05）。然而，这在成人温暖恢复中并没有显着差异。在太阳光照下暴露1600 J/m^2，我们停止了感染实验，因为在小鼠中被沉没造成的损害造成的损害。如上所述，在太阳光中，uv-b的有效辐射剂量与人工UV-B.IT相比，与人造uv-iit相比，太阳光的有效辐射量很高。 UV-B。在800 j/m^2的UV-B暴露于UV-B中，导致免疫力降低，并增强了尾car体入入皮肤组织中。这些表明，在太阳光中的UV-B不幸的是血吸虫病感染。此外，Wemust调查了人类健康，以通过在800 j/m^2的实验中使用温度控制设备进行实验，并通过太阳能暴露于体内的cercariae。较少的