Deterioration action by solar ultraviolet rays exposure on infection and symptom of Schistosomiasis and in symptom, and evaluation it

在这项研究中，我们实验了由太阳紫外线照射引起的免疫能力的变化以及这种变化对疾病感染的影响，并检查紫外线是否参与疾病感染。用曼氏血吸虫尾蚴进行感染实验，结果表明，在400 J/m^2的人工紫外线（UV-B）照射下，曼氏血吸虫尾蚴侵入皮肤组织和成虫体温恢复均较未照射组显著增高，使曼氏血吸虫病加重400 J/m^2 UV-B日光照射组各尾蚴侵入皮肤组织数和成虫温复数与对照组比较差异均无显著性（P> 0.01）在含有800 J/m^2 UV-B的太阳光照射下，红外线使小鼠体温升高，因此我们用冰袋进行行为疗法抑制 ...更多信息 mo调节。在免疫方面，日光照射后7 d，小鼠的CD_4/CD_8下降到显著的最低值，但2周后又恢复正常。感染尾蚴数较对照组明显增加（P<0.05）。另外，在1600 J/m^2的太阳光照射下，由于小鼠中暑而导致损伤，我们停止了感染实验，考虑到太阳光中UV-B的有效辐射剂量比人工UV-B高。与人工UV-B的非连续谱相比，连续谱的太阳光可能需要更大的剂量才能达到相同的效果。800 J/m^2的UV-B太阳光照射可导致免疫功能下降，并促进尾蚴侵入皮肤组织。说明太阳光中的UV-B对血吸虫感染有加重作用。此外，我们还必须通过温度控制装置进行800 J/m^2以上的日光照射实验，以了解人体内尾蚴的生长情况。少

On this study, we experimented about a change of immunological ability induced by exposure of solar ultraviolet rays and an influence of the change on a sick infection, and examine whether ultraviolet rays participates in sick infection, or not. We used cercariae of Schistosoma mansoni for infectious experiments.In results of artificial ultraviolet rays (UV-B) irradiation with 400 J/m^2 of UV-B, Schistosomiasis became worsen by UV-B irradiation, because both cercariae invaded into skin tissue and adult warm recovered increased significantly as comparison with non-irradiation group (p<0.01).In solar light exposure contained with 400 J/m^2 of UV-B, there was not significant difference in numbers of each cercariae invaded into skin tissue and adult warm recovered as comparison with non-exposure group (control group).In solar light irradiation contained with 800 J/m^2 of UV-B, the body temperature of mice increased by infrared rays, so we used with ice pack for restrain it by behavior ther … More mo-regulation. On immunity, CD4/CD8 in mice decreased to the significant minimum value in 7 days after solar light exposure, but it recovered in after 2 weeks. The cercariae invaded increased significantly compared with control group (p<0.05). However, it was not significant difference in adult warm recovered.Further more in solar light exposure with 1600 J/m^2, we stopped infection experiments because damages induced by sunstroke in mice.As considerations, the effective radiation dose of UV-B in solar light was high compared with artificial UV-B. It is guessed that continuous spectrum of solar light need much dose to get equal effects compared with discontinuity spectra of artificial UV-B.Exposure to solar light at 800 J/m^2 of UV-B caused depression of immunity, and it enhanced cercariae to invade into skin tissue. These suggest that UV-B in solar light becomes worsen in infection of Schistosomiasis. Furthermore, wemust investigate for human health about growing up of cercariae in the body with solar light exposure through experiments over 800 J/m^2 with temperature control equipment. Less