Deterioration action by solar ultraviolet rays exposure on infection and symptom of Schistosomiasis and in symptom, and evaluation it

在本研究中，我们实验了太阳紫外线照射引起的免疫能力的变化及其对疾病感染的影响，并研究了紫外线是否参与了疾病感染。我们用曼氏血吸虫尾蚴进行感染性实验。400 J/m^2的人工紫外线照射组血吸虫病加重，尾蚴侵入皮肤组织和成人体温恢复均明显高于未照射组（p<0.01）。紫外线照射量为400 J/m^2的太阳光照下，与未照射组（对照组）相比，侵入皮肤组织的尾蚴数和成体体温恢复数均无显著差异。在800 J/m^2 UV-B的太阳光照下，红外辐射使小鼠体温升高，因此我们用冰敷法通过行为调节来抑制体温升高。在免疫方面，小鼠的CD4/CD8在日光照射后7天降至最低，但在2周后恢复。侵染尾蚴数与对照组相比显著增加（p<0.05）。成人热恢复无显著性差异。此外，在1600 J/m^2的日光照射下，由于小鼠中暑引起的损伤，我们停止了感染实验。考虑到太阳光中UV-B的有效辐射剂量比人工UV-B高。推测太阳光的连续光谱与人工UV-B的不连续光谱相比，需要更大的剂量才能达到相同的效果。暴露在800 J/m^2的紫外线下，免疫功能下降，促进尾蚴向皮肤组织的侵袭。说明日光下的UV-B对血吸虫病的感染有加重作用。此外，我们必须通过温度控制设备，通过800 J/m^2以上的太阳光照实验，研究尾蚴在人体中的生长对人体健康的影响。少

On this study, we experimented about a change of immunological ability induced by exposure of solar ultraviolet rays and an influence of the change on a sick infection, and examine whether ultraviolet rays participates in sick infection, or not. We used cercariae of Schistosoma mansoni for infectious experiments.In results of artificial ultraviolet rays (UV-B) irradiation with 400 J/m^2 of UV-B, Schistosomiasis became worsen by UV-B irradiation, because both cercariae invaded into skin tissue and adult warm recovered increased significantly as comparison with non-irradiation group (p<0.01).In solar light exposure contained with 400 J/m^2 of UV-B, there was not significant difference in numbers of each cercariae invaded into skin tissue and adult warm recovered as comparison with non-exposure group (control group).In solar light irradiation contained with 800 J/m^2 of UV-B, the body temperature of mice increased by infrared rays, so we used with ice pack for restrain it by behavior ther … More mo-regulation. On immunity, CD4/CD8 in mice decreased to the significant minimum value in 7 days after solar light exposure, but it recovered in after 2 weeks. The cercariae invaded increased significantly compared with control group (p<0.05). However, it was not significant difference in adult warm recovered.Further more in solar light exposure with 1600 J/m^2, we stopped infection experiments because damages induced by sunstroke in mice.As considerations, the effective radiation dose of UV-B in solar light was high compared with artificial UV-B. It is guessed that continuous spectrum of solar light need much dose to get equal effects compared with discontinuity spectra of artificial UV-B.Exposure to solar light at 800 J/m^2 of UV-B caused depression of immunity, and it enhanced cercariae to invade into skin tissue. These suggest that UV-B in solar light becomes worsen in infection of Schistosomiasis. Furthermore, wemust investigate for human health about growing up of cercariae in the body with solar light exposure through experiments over 800 J/m^2 with temperature control equipment. Less