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Comparison of contributions of thermosensitive tissues in central nervous system on heat loss responses in rabbits

家兔中枢神经系统热敏组织对热损失反应贡献的比较

基本信息

批准号：
63570082
负责人：
OHWATARI Nobu
金额：
$ 1.34万
依托单位：
Institute of Tropical Medicine, Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

项目摘要

The preoptic area and anterior hypothalamus(PO/AH), medullary reticural formation(MRF) and spinal cord as thermosensitive tissues in the central nervous system were locally heated with an argon laser in order to induce heat loss responses in rabbits. Increases in ear skin temperature and respiratory rate and decrease in rectal temperature evoked by local heating were compared among the tissues.1. PO/AH and MRF Heating :(1)The Ar laser irradiation guided with a glass fiber is very useful to heat a small area in deep body tissue. (2)PO/AH and MRF were locally heated with Ar laser under no influence of thermal conduction though the thermal signals were transmitted by neurons. (3) The minimal Ar laser powers to induce the heat loss responses were 14.5 mW for PO/AH and 19.0 mW for MRF and it was significant difference,and thermal distributions of increase in brain temperature by Ar laser irradiations at these powers were calculated. (4)The ratio of PO/AH to MRF in products of heated volume and increase in temperature of over 0.50 ﾟC was 1:2.94.2. Spinal Heating : (1)The argon laser guided with a glass fiber(0.4 mm in diameter) irradiated inside a guide tube(0.8 mm in diameter) which was implanted into the peridural space from lumbar vertebrae (L4/L5) to thoracic vertebrae(Th1). (2)The length of spinal cord increased more than 0.5 ﾟC and maximal increase in temperature of spinal cord depended on the irradiation power as follows: 7.3 mm and 1.32 ﾟC for 40 mW, 10.5 mm and 2.02ﾟC for 60 mW, 13.1 mm and 2.73ﾟC for 80 mW. (3) At all locations from Th1 to L4, the heat loss responses were evoked. (4) The heat loss responses induced by the lumbar spinal heating were no significant difference compared with that by the thoracic spinal heating.

用氩气激光局部加热兔视前区、下丘脑前部（PO/AH）、髓质网状结构（MRF）和脊髓作为中枢神经系统的热敏组织，以诱导热损失反应。比较局部加热引起的耳部皮肤温度和呼吸频率升高和直肠温度降低。PO/AH和MRF加热：(1)由玻璃纤维引导的Ar激光照射对人体深部组织的小区域加热非常有用。(2)通过神经元传递热信号，在不影响热传导的情况下，用Ar激光局部加热PO/AH和MRF。(3)诱导PO/AH和MRF热损失响应的最小Ar激光功率分别为14.5 mW和19.0 mW，两者存在显著性差异，并计算了这两个功率下Ar激光辐照脑温升高的热分布。(4)在加热体积和温度升高超过0.50℃的产品中，PO/AH与MRF的比例为1:2.94.2。脊柱加热：(1)氩气激光引导玻璃纤维（直径0.4 mm）照射在直径0.8 mm的导管内，导管从腰椎（L4/L5）至胸椎（Th1）植入硬膜外间隙。(2)不同辐照功率下，脊髓长度增加幅度均在0.5ºC以上，脊髓温度最大增加幅度分别为：40mw时7.3 mm和1.32ºC， 60mw时10.5 mm和2.02ºC， 80mw时13.1 mm和2.73ºC。(3)从Th1到L4的所有位置都有热损失响应。(4)腰椎加热引起的热损失反应与胸椎加热引起的热损失反应无显著差异。