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Comparison of contributions of thermosensitive tissues in central nervous system on heat loss responses in rabbits

家兔中枢神经系统热敏组织对热损失反应贡献的比较

基本信息

批准号：
63570082
负责人：
OHWATARI Nobu
金额：
$ 1.34万
依托单位：
Institute of Tropical Medicine, Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

项目摘要

The preoptic area and anterior hypothalamus(PO/AH), medullary reticural formation(MRF) and spinal cord as thermosensitive tissues in the central nervous system were locally heated with an argon laser in order to induce heat loss responses in rabbits. Increases in ear skin temperature and respiratory rate and decrease in rectal temperature evoked by local heating were compared among the tissues.1. PO/AH and MRF Heating :(1)The Ar laser irradiation guided with a glass fiber is very useful to heat a small area in deep body tissue. (2)PO/AH and MRF were locally heated with Ar laser under no influence of thermal conduction though the thermal signals were transmitted by neurons. (3) The minimal Ar laser powers to induce the heat loss responses were 14.5 mW for PO/AH and 19.0 mW for MRF and it was significant difference,and thermal distributions of increase in brain temperature by Ar laser irradiations at these powers were calculated. (4)The ratio of PO/AH to MRF in products of heated volume and increase in temperature of over 0.50 ﾟC was 1:2.94.2. Spinal Heating : (1)The argon laser guided with a glass fiber(0.4 mm in diameter) irradiated inside a guide tube(0.8 mm in diameter) which was implanted into the peridural space from lumbar vertebrae (L4/L5) to thoracic vertebrae(Th1). (2)The length of spinal cord increased more than 0.5 ﾟC and maximal increase in temperature of spinal cord depended on the irradiation power as follows: 7.3 mm and 1.32 ﾟC for 40 mW, 10.5 mm and 2.02ﾟC for 60 mW, 13.1 mm and 2.73ﾟC for 80 mW. (3) At all locations from Th1 to L4, the heat loss responses were evoked. (4) The heat loss responses induced by the lumbar spinal heating were no significant difference compared with that by the thoracic spinal heating.

用氩激光局部加热家兔视前区、下丘脑前部（PO/AH）、延髓网状结构（MRF）和脊髓等温度敏感组织，诱发热损失反应。比较局部加热引起的耳皮肤温度和呼吸频率的升高以及直肠温度的降低. PO/AH和MRF加热：（1）用玻璃纤维引导的Ar激光照射对于加热深部组织中的小区域非常有用。(2)PO/AH和MRF在不受热传导影响的情况下用Ar激光局部加热，尽管热信号是由神经元传递的。(3)产生热损失反应的最小Ar激光功率PO/AH为14.5mW，MRF为19.0mW，两者有显著性差异，并计算了这两种功率下Ar激光引起脑温升高的热分布。（4）体积升温大于0.50 ℃的产物中PO/AH与MRF之比为1：2.94。脊柱加热：（1）在从腰椎（L4/L5）到胸椎（Th 1）的硬膜外间隙植入的导管（直径0.8mm）内照射由玻璃纤维（直径0.4mm）引导的氩激光。（2）脊髓长度增加0.5 ℃以上，脊髓温度最大增加值与照射功率有关：40 mW为7.3mm和1.32 ℃，60 mW为10.5mm和2.02 ℃，80 mW为13.1mm和2.73 ℃。(3)在从Th 1到L4的所有位置，诱发热损失反应。(4)腰椎加热引起的热损失反应与胸椎加热相比无显著差异。