Polyunsaturated fatty acids in plasma and mononuclear cell phospholipids of patients with atopic eczema.

特应性湿疹患者血浆和单核细胞磷脂中的多不饱和脂肪酸。

• 批准号: 07670432
• 负责人: NASU Yutaka
• 金额: $ 1.41万
• 依托单位: NAGANO COLLEGE OF NURSING
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670432/
• 关键词: Atopic-Eczema; Polyunsaturated Fatty Acid; Phospholipid; Gamma-linolenic Acid; Linoleic Acid; Arachidonic Acid; リノレン酸; 慢性炎症性疾患

Recent studies of polyunsaturated fatty acids (PUFA) in plasma and blood cell components of patients with atopic diseases have indicated disordered fat metabolism as linoleic acid (18 : 2n-6) tends to be increased while the more unsaturated fatty acids, such as gamma-linolenic acid (18 : 3n-6) and arachidonic acid (20 : 4n-6) are present in decreased amounts. In atopic eczema patients, the delta-6-desaturase function should be impaired, then the amount of linoleic acid should be increased, on the other hand those of the linoleic acid metabolites should be decreased. And so when the direct metabolite of linoleic acid, gamma-linolenic acid, is adminostered for the patients, then the symptoms of this disease should be disappeared.No significant differences were seen between control and patients before treatment. By the treatment of EFA,dihomogamma-linolenic acid (20 : 4n-6) was significantly decreased and behenic acid (22 : 1n-9? ) significantly increased.Linoleic acid (18 : 2n-6) of patients looked like to be increased compared with control group and decreased after treatment, though not significantly. And more unsaturated fatty acids, such as homogamma-Iinolenic acid and arachidonic acid looked decreased after treatment.

最近对特应性疾病患者血浆和血细胞成分中多不饱和脂肪酸（PUFA）的研究表明，脂肪代谢紊乱，因为亚油酸（18：2n-6）倾向于增加，而更不饱和的脂肪酸，如γ-亚麻酸（18：3 n-6）和花生四烯酸（20：4 n-6）的含量减少。在特应性湿疹患者中，δ-6-去饱和酶功能应受损，然后亚油酸的量应增加，另一方面亚油酸代谢产物的量应减少。因此，当给予患者亚油酸的直接代谢产物γ-亚麻酸时，这种疾病的症状应该消失，对照组与治疗前患者之间没有显著差异。经EFA处理后，二高γ-亚麻酸（20：4 n-6）含量显著降低，二十二烷酸（22：1 n-9？亚油酸（18：2n-6）与对照组比较，治疗后虽有下降，但无统计学意义。治疗后高γ-亚麻酸、花生四烯酸等不饱和脂肪酸减少。

项目成果

D. C. E. Nordstrom, VEAHonkanen, Y. Nasu, E. Antila, C. Friman, Y. T. Konttinen: "Alpha-linolenic acid in the treatment of rheumatoid arthritis, A double-blind, placebo-controlled and randomized study : flaxseed vs, safflower seed" Rheumatol Int. 14. 231-

D. C. E. Nordstrom、VEAHonkanen、Y. Nasu、E. Antila、C. Friman、Y. T. Konttinen：“α-亚麻酸治疗类风湿性关节炎，一项双盲、安慰剂对照和随机研究：亚麻籽与红花籽”

D.C.E.Nordstrom, VEA Honkanen, Y.Nasu, E.Antila, C.Friman, Y.T.Konttinen: "Alpha-linolenic acid in the treatment of rheumatoid arthritis. Adouble-blind,placebo-controlled and randomized study : flaxseed v.s.safflower seed." Rheumatol Int. 14. 231-234 (199

D.C.E.Nordstrom、VEA Honkanen、Y.Nasu、E.Antila、C.Friman、Y.T.Konttinen：“α-亚麻酸治疗类风湿性关节炎。一项双盲、安慰剂对照和随机研究：亚麻籽与红花籽。”

D.C.E.Nordstrom, V.E.A.Honkanen, Y.Nasu, E.Antila, C.Friman, Y.T.Konttinen: "Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study : Flaxseed vs.Safflower seed." Rheumatol Int. 14. 231-234 (

D.C.E.Nordstrom、V.E.A.Honkanen、Y.Nasu、E.Antila、C.Friman、Y.T.Konttinen：“α-亚麻酸治疗类风湿性关节炎。一项双盲、安慰剂对照和随机研究：亚麻籽与红花籽