Immunocytochemical studies on beta-amyloidogenesis

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Deposition of beta-amyloid in senile plaques and in the walls of the cerebral vessels is the earliest pathological lesions in Alzheimer's disease and considered to be tightly associated with its pathogenesis. In this study, we established specific antibodies that recognize the heterogenous amino- and carboxyl-termini of amyloid beta protein (Abeta). We found (1) by immunocytochemistry that full-length Abeta42(43) as well as amino-terminally modified and truncated Abeta42(43) (i.e., those beginning at recemized or isomerized Asp 1 or pyroglutamate 3) deposit in diffuse plaques, and that (2) Abeta3pyroGlu-42(43) is the most predominant species that deposit in cerebral parenchyme as amyloid.