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Endothelial function and exercise capacity in patients with chronic heart failure

慢性心力衰竭患者的内皮功能和运动能力

基本信息

批准号：
07670802
负责人：
NAKAMURA Motoyuki
金额：
$ 1.47万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670802/
关键词：
Endothelium Exercise Heart failure Peripheral blood flow 内皮(血管)運動耐容能末梢血管

项目摘要

We have investigated clinical significance of peripheral endothelial dysfunction in patients with chronic heart failure. There was a significant correlation between exercise capacity and periheral vascular dilatory function determined by acetylcholine administration in patients with chronic heart failure (Am J Cardiol 77 ; 98-102 : 1995). Furthermore, we have found an improvement of lower limb vasodilatory reserve capacity after open heart surgery for valvular heart disease, and found that changes in the vascular function were significantly correlated with changes in exercise capacity as determined by peak oxygen uptake (paper in submission). These observations suggest that endothelium-dependent peripheral vasodilatory capacity may be important in the regulation of exercise-induced vasodilation in heart failure. We have also examined effects of L-arginine (a substrate of endothelium-derived nitric oxide) on lower limb peripheral vasodilatory reserve and exercise capacity in patients with chronic heart failure (n=14). Although reactive hyperemic blood flow in the calf was significantly augmented by L-arginine infusion, exercise capacity did not improve immediately. These results will be presented in an international medical meeting (19th European Society of Cardiology, Stockholm, 1997).

我们研究了慢性心力衰竭患者外周内皮功能障碍的临床意义。慢性心力衰竭患者的运动能力和通过给予乙酰胆碱测定的外周血管扩张功能之间存在显着相关性(Am J Cardiol 77；98-102：1995)。此外，我们发现心脏瓣膜病心脏直视手术后下肢血管舒张储备能力有所改善，并发现血管功能的变化与峰值摄氧量确定的运动能力的变化显着相关（提交中的论文）。这些观察结果表明，内皮依赖性外周血管舒张能力可能在心力衰竭运动诱发的血管舒张调节中发挥重要作用。我们还研究了 L-精氨酸（内皮源性一氧化氮的底物）对慢性心力衰竭患者下肢外周血管舒张储备和运动能力的影响 (n=14)。尽管L-精氨酸输注显着增加了小腿反应性充血血流量，但运动能力并没有立即改善。这些结果将在国际医学会议上公布（第 19 届欧洲心脏病学会，斯德哥尔摩，1997 年）。