Development of Cardiovascular Risk Scoring System for Japanses Population

一些研究表明，在西方人群中，新的生物标记物(高敏CRP、BNP、尿白蛋白)对心血管事件(CVE)是有用的。然而，在日本人群中，这些标记物预测CVE的可行性仍然未知。我们已经报道了包括脂蛋白比率在内的这些生物标志物在我们人群中预测中风、心力衰竭和心肌梗死的有效性。在这些标记物中，血浆BNP单独或与其他标记物联合使用的预测价值与已建立的评分系统相近或更好。在这些报道的基础上，我们正在探索一种新的、有用的评分系统来预测日本普通人群中的CVE。

Several studies have suggested usefulness of new biomarkers (high-sensitive CRP, BNP, urine albumin) for cardiovascular events (CVE) in western population. However, feasibility of these markers for predicting CVE remains unknown in the Japanese population. We have reported usefulness of these biomarkers including lipoprotein ratio for predicting stroke, heart failure, and myocardial infarction in our population. Of these markers, the predictive value of plasma BNP singly or combination with other markers is similar or superior to compare with that of the established scoring system. On the basis of these reports, we are exploring a novel and useful scoring system for predicting CVE in the Japanese general population.