Definition and validity of chronic kidney disease as a cardiovascular risk factor in the community-based population

慢性肾病作为社区人群心血管危险因素的定义和有效性

• 批准号: 20590836
• 负责人: NAKAMURA Motoyuki
• 金额: $ 2.91万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590836/
• 关键词: 慢性腎臓病; 心筋梗塞; 脳卒中; 心不全; 尿蛋白; 腎機能; 腎臓; CRP; BNP; リスク; 腎臓病; 住民; 健診; 炎症

The definition of chronic kidney disease (CKD) which effectively discriminates high-risk subjects for cardiovascular events (CVE) from the Japanese general population has yet to be established. The aim of this study was to examine which definition of CKD might be useful for the prediction of CVE in our population. Baseline data including serum creatinine and proteinuria were determined in community- dwelling adults (n=14131, age=63). Estimated glomerular filtration rate (eGFR) was calculated using a modified MDRD equation, and CKD was defined by the three methods : (1) eGFR<60, (2) eGFR<60 or proteinuria positive, (3) eGFR<60 or proteinuria trace. CVE (stroke, heart failure, myocardial infarction/sudden death) were surveyed prospectively (mean follow-up = 2.7 years). As results, the most powerful definition of CKD for discriminating non-CKD in terms of CVE risk prediction was the definition of (3) (HR=1.36, 95%CI=1.07-1.74 ; p<0.05). In conclusion, the most useful definition of CKD for CVE risk-prediction in the Japanese general population appears to be eGFR<60 and/or urine protein trace.

尚未确定可有效区分心血管事件（CVE）高风险受试者与日本普通人群的慢性肾脏疾病（CKD）定义。本研究的目的是检查CKD的定义可能有助于预测我们人群中的CVE。基线数据包括血清肌酐和蛋白尿测定社区居住的成年人（n = 14131，年龄= 63）。采用改良MDRD公式计算肾小球滤过率（eGFR），以eGFR <60、eGFR <60或蛋白尿阳性、eGFR <60或微量蛋白尿3种方法定义CKD。对CVE（卒中、心力衰竭、心肌梗死/猝死）进行了前瞻性调查（平均随访= 2.7年）。结果表明，在CVE风险预测方面，用于区分非CKD的最有力的CKD定义是（3）的定义（HR = 1.36，95%CI = 1.07 - 1.74; p <0.05）。总之，在日本一般人群中，最有用的CKD定义是eGFR <60和/或尿蛋白微量。

项目成果

危険因子「BNP」

风险因素“BNP”

• 发表时间: 2011
• 期刊: 動脈硬化予防 印刷中
• 作者: Abiko A;Makita S;Naganuma Y;Nagai M;Nakamura M;Yasukatsu Izumi;中村元行
• 通讯作者: 中村元行

Iwate KENCO Study Groups. Gender-specific risk stratification with plasma B-type natriuretic peptide for future onset of congestive heart failure and mortality in the Japanese general population.

岩手县 KENCO 研究小组。

• 发表时间: 2010
• 期刊: Int J Cardiol 143(2)
• 作者: Nakamura M;Tanaka F;Onoda T;Takahashi T;Sakuma M;Kawamura K;Tanno K;Ohsawa M;Itai K;Sakata K;Makita S
• 通讯作者: Makita S

Peripheral-BP, Central-BP, and PWV: Which is the Most Useful Predictor for Cardiovascular Events and Death in the General Population

外周血压、中枢血压和 PWV：哪个是一般人群心血管事件和死亡最有用的预测因子

• 发表时间: 2010
• 作者: 小野寺正幸;中村元行;他
• 通讯作者: 他

Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a useful marker for early-stage carotid atherosclerosis

• DOI: 10.1016/j.metabol.2009.09.009
• 发表时间: 2010-05-01
• 期刊: METABOLISM-CLINICAL AND EXPERIMENTAL
• 影响因子: 9.8
• 作者: Tamada, Makiko;Makita, Shinji;Nakamura, Motoyuki
• 通讯作者: Nakamura, Motoyuki

Is Plasma B-type Natriuretic Peptide Measurement Valid for Prediction of Cardiovascular Events and Death in Chronic Kidney Disease? A Community-based Longitudinal Study.

血浆 B 型利尿钠肽测量对于预测慢性肾病患者的心血管事件和死亡是否有效？

• 发表时间: 2008
• 作者: 佐久間雅文;中村元行;他
• 通讯作者: 他