Vestibulo-Autonomic Reflex and Vestibulo-Ocular Reflex in Space Adaptation Syndrome

空间适应综合征中的前庭自主反射和前庭眼反射

• 批准号: 07807011
• 负责人: MIZUTA Keisuke
• 金额: $ 1.34万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07807011/
• 关键词: Space Adaptation Syndrome; Vestibulo-autonomic reflex; Vestibulo-ocular reflex; Rhesus monkey; Double rotating stimulus

We tried to investigate the mechanism of space adaptation syndrome to reveal a relationship between changes of the vestibulo-autonomic reflex and those of the vestibulo-ocular reflex from 1995 to 1996. Our study did not obtained so many data since we had much time to care and train a rhesus monkey. The equipment we used at our university to invoke spatial disorientation in animal satisfactorily simulates the occurrence of space adaptation syndrome. Futher experiment that we continue will reveal some important results as follows : 1.We confirm that Bolivian rhesus monkeys are suitable animals in simulation experiments, since they exhibit symptoms very similar to those experienced by astronaut during space motion sickness. 2.Double rotation stimulation (yaw and pitch ax es) is effective in simulating space adaptation syndrome on earth. 3.In the present study, since there would be no obvious effects of phase lag and velocity differences between yaw and pitch rotation on symptoms of space … More adaptation syndrome, we should apply a simpse stimulation strategy in which velocity of yaw rotation is equivalent to that of pitch rotation without phase lag. 4.An increase of heart rate and a decrease in blood pressure will be observed when the rhesus monkeys were exposed to double rotation stimuli, which seems to result from the vestibulo-autonomic reflex.We will infer that the inputs producing these responses come from the otolith receptors. These results should indicate a modification of vestibulo-sympathetic reflexes. 5.Power spectral analysis of the heart R-R interval would be also consistent with sympathetic excitation, further supporting the parallel with space adaptation syndrome. 6.A significant change would not be observed in measurements of facial blood flow using a laser Doppler technique, although a slight decrease would be observed. 7.Double rotation stimulation will cause spontaneous horizontal eye movements, so-called nystagmus, although vertical nystagmus would not observe. 8.We shall analyze the time constant and gain of slow phase eye velocity to ex amine the nature of horizontal nystagmus during double ax es rotation. It would be possible that a modification of the neural integrator and velocity storage resulted from the double rotation stimulation. Our study shall provide contributions toward revealing the mechanisms of space adaptation syndrome. Less

1995 ~ 1996年，我们试图探讨空间适应综合征的发病机制，以揭示前庭-自主反射与前庭-眼反射的变化关系。我们的研究没有得到那么多的数据，因为我们有很多时间去照顾和训练一只恒河猴。我们在我们的大学使用的设备，唤起空间定向障碍的动物满意地模拟空间适应综合征的发生。我们继续进行的进一步实验将揭示以下一些重要结果：我们确认玻利维亚恒河猴是模拟实验的合适动物，因为它们表现出与宇航员在太空晕动病中经历的症状非常相似。2.双旋转刺激（偏航轴和俯仰轴）是模拟地球空间适应综合征的有效方法。3.在本研究中，由于偏航和俯仰旋转的相位滞后和速度差对空间适应综合征的症状没有明显的影响，所以我们应该采用一种简单的刺激策略，即偏航旋转的速度与俯仰旋转的速度相等，没有相位滞后。4.当恒河猴暴露于双旋转刺激时，会观察到心率增加和血压降低，这似乎是由前庭自主反射引起的。我们将推断产生这些反应的输入来自耳石受体。这些结果应该表明前庭交感反射的改变。5.心脏R-R间期的功率谱分析也将与交感兴奋相一致，进一步支持与空间适应综合征的平行。6.在使用激光多普勒技术测量面部血流时，虽然会观察到轻微的减少，但不会观察到明显的变化。7.双旋转刺激会引起自发的水平眼动，即所谓的眼震，尽管垂直眼震不会出现。8.我们将分析慢相眼速度的时间常数和增益，以探讨双轴旋转时水平眼震的性质。双旋转刺激可能导致神经积分器和速度存储的改变。本研究将为揭示空间适应综合征的发生机制做出贡献。少

项目成果

松波謙一: "慢性リスザル用モンキーチェア・記録装置の試作" 日本宇宙航空環境医学会誌. (印刷中). (1997)

Kenichi Matsunami：“用于慢性松鼠猴的猴椅和记录装置的原型”，日本航空航天与环境医学学会杂志（1997 年出版）。