Studies on the mechanisms for vestibular adaptation of the bilateral labyrinthectomized infant rat

单侧迷路切除动物表现为平衡功能障碍和眼球震颤。然而，这些发现通常会在一段时间后消失。平衡功能障碍的改善被认为是由大脑的可塑性引起的，称为前庭代偿。双侧迷路切除动物仍存在平衡功能障碍。因此，通常的前庭代偿在双侧迷路动物中不容易起作用。另一方面，先天性双侧迷路缺陷者表现出正常的平衡发育。预测新生动物双侧迷路破坏后，平衡功能发育正常。双侧迷路切除新生动物平衡功能障碍的改善与脑可塑性有关。本研究旨在探讨这一机制，特别关注MAP激酶的参与对脑神经元分化的影响。我们破坏了新生大鼠的双侧迷宫。双侧迷路切除新生大鼠平衡功能发育正常。MAP激酶在迷宫破坏后第4天激活。然而，我们发现成年大鼠和新生大鼠之间的差异不大。因此，我们认为MAP激酶在大脑可塑性中并不起重要作用。

Unilateral labyrinthectomized animal shows dysfunction of equilibrium and nystagmus. However these findings usually disapear after a while. It is thought that the improvement of dysfunction of equilibrium is caused by the plasticity of the brain which is called vestibular compensation. Bilateral labyrinthectomized animal remains the dysfunction of equilibrium. Therefore, usual vestibular compensation is not easy to work in bilateral labyrinthectomized animal. On the other hand, person with congenital deficit of bilateral labyrinths shows normal devalopment of equilibrium. It is forecast that the development of the equilibrium function is normal when bilateral labyrinths of newborn animalare destroyed. The improvement of dysfunction of equilibrium in bilateral labyrinthectomized newborn animal is due to the mechanism which is concerned with the plasticity of the brain.We aimed to examine this mechanism, Especially, we foces on the participation of MAP kinase which affects on the differentiation of the nuron of the brain.We destroyed bilateral labyrinths of newborn rats. These bilateral labyrinthectomized newborn rats showed normal development of the function of equilibrium. MAP kinase ia activated 4 days after the destruction of labyrinth. However, we saw little difference between in adult rats and in newborn rats. Therefore, it was thought that MAP kinase did not play an important role in the plasticity of the brain.