Clinical usefulness of Tc-99m GSA hepatic scintigraphy in chronic hepatitis

为评价干扰素治疗前后肝功能储备的变化，我们对26例干扰素治疗前和10例干扰素治疗前后的慢性肝炎患者进行了~(99m)Tc-DTPA-半乳糖基人血清白蛋白(TC-99m GSA)肝脏显像，结果表明，干扰素治疗前慢性肝炎患者肝脏摄取~(99m)TcGSA的程度与肝细胞坏死和纤维化程度呈正相关。在干扰素治疗前，肝细胞坏死和纤维化程度较轻的患者和~(99m)TcGSA肝显像显示2级或以下的患者，干扰素治疗效果良好。~(99m)TcGSA肝摄取分级在干扰素治疗前后无明显变化，~(99m)TcGSA肝显像有助于确定慢性肝炎患者干扰素治疗的适应证。然而，用~(99m)Tc-GSA肝显像评价干扰素治疗效果可能有一定难度。

To evaluate the changes in hepatic functional reserve before and after interferon therapy, we performed Tc-99m DTPA-galactosyl human serum albumin (Tc-99m GSA) hepatic scintigraphy in 26 patients before interferon therapy and 10 patients before and after interferon therapy.The grade of the hepatic uptake of Tc-99m GSA by visual assessment correlated well with the extent of hepatocellular necrosis and fibrosis in patients with chronic hepatitis before interferon therapy. Good response of interferon therapy was obseved in patients with less hepatocellular necrosis and fibrosis on histological assessment and in patients showing grade 2 or less on Tc-99m GSA hepatic scintigraphy before interferon therapy. The grade of hepatic uptake of Tc-99m GSA demonstrated no change before and after interferon therapy.Tc-99m GSA hepatic scintiguraphy is useful to determine the indication of interferon therapy in patients with chronic hepatitis. However, it might be difficult to evaluate the effect of interferon therapy by Tc-99m GSA hepatic scintigraphy.