Clinical usefulness of Tc-99m GSA hepatic scintigraphy in chronic hepatitis

Tc-99m GSA 肝脏闪烁显像在慢性肝炎中的临床应用

• 批准号: 07671016
• 负责人: TOMIGUCHI Seiji
• 金额: $ 1.41万
• 依托单位: KUMAMOTO UNIVERSITY HOSPITAL
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671016/
• 关键词: Tc-99m GSA; chronic hepatitis; inter feron; TIPS; ^<99m>Tc GSA; Tc-99m GSA; C型慢性肝炎; インターフェロン治療

To evaluate the changes in hepatic functional reserve before and after interferon therapy, we performed Tc-99m DTPA-galactosyl human serum albumin (Tc-99m GSA) hepatic scintigraphy in 26 patients before interferon therapy and 10 patients before and after interferon therapy.The grade of the hepatic uptake of Tc-99m GSA by visual assessment correlated well with the extent of hepatocellular necrosis and fibrosis in patients with chronic hepatitis before interferon therapy. Good response of interferon therapy was obseved in patients with less hepatocellular necrosis and fibrosis on histological assessment and in patients showing grade 2 or less on Tc-99m GSA hepatic scintigraphy before interferon therapy. The grade of hepatic uptake of Tc-99m GSA demonstrated no change before and after interferon therapy.Tc-99m GSA hepatic scintiguraphy is useful to determine the indication of interferon therapy in patients with chronic hepatitis. However, it might be difficult to evaluate the effect of interferon therapy by Tc-99m GSA hepatic scintigraphy.

评价干扰素治疗前后肝脏储备功能的变化，我们进行了Tc-99 mDTPA-半乳糖基人血清白蛋白对26例干扰素治疗前和10例干扰素治疗前后的肝摄取~（99）Tc-γ-GSA显像结果进行了比较，并对肝摄取~（99）Tc-γ-GSA显像的分级进行了分析。在干扰素治疗前慢性肝炎患者中，通过视觉评估的99 mGSA与肝细胞坏死和纤维化的程度相关。在组织学评估肝细胞坏死和纤维化较少的患者中以及在干扰素治疗前Tc-99 mGSA肝动脉造影显示2级或更低的患者中观察到干扰素治疗的良好反应。~（99 m）Tc-GSA肝摄取分级在干扰素治疗前后无明显变化，~（99 m）Tc-GSA肝摄取显像对确定干扰素治疗慢性肝炎的适应证有一定的参考价值。但用~（99）Tc-GSA肝动脉造影评价干扰素疗效可能有一定困难。

项目成果

冨口 静二: "Correlation of Tc-99m GSA Hepatic Studies with Biopsies in Patients with chronic Active Hepatitis." Clinical Nuclear Medicine. 20. 717-720 (1995)

Seiji Tomiguchi：“慢性活动性肝炎患者 Tc-99m GSA 肝脏研究与活检的相关性。”20. 717-720 (1995)