Application of SPECT/CT system in diagnosis of ischemic heart disease

评价SPECT/CT在缺血性心脏病诊断中的基础和临床应用价值。利用CT图像对心肌灌注SPECT进行衰减、散射和分辨率校正。在体模研究中，所有校正均改善了均匀性、缺陷对比度和计数定量。在临床研究中，除了LAD区域的特异性降低外，所有校正均提高了诊断缺血性心脏病的敏感性和特异性。然而，特异性的改善通过使用转换的舒张末期（CED）图像得到补偿。此外，心肌放射性占注射剂量的百分比被认为是评价心肌血流储备的良好指标。

Fundamental and clinical usefulness of SPECT/CT in the diagnosis of ischemic heart disease was evaluated. Attenuation, scatter and resolution correction for myocardial perfusion SPECT were performed by using CT image. In phantom study, uniformity, defect contrast and count quantification improved with all corrections. In clinical study, sensitivity and specificity in the diagnosis of ischemic heart disease improved with all corrections except decrease in the specificity of LAD territory. However, improvement in the specificity was compensated by using a converted endodiastolic(CED) image. Furthermore,% myocardial radioactivity to the injected dose was considered to be the good index to evaluate the myocardial flow reserve.