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Fundamental and clinical evaluation of attenuation correcting using TCT on SPECT

SPECT 上 TCT 衰减校正的基础和临床评估

基本信息

批准号：
13670952
负责人：
TOMIGUCHI Seiji
金额：
$ 1.98万
依托单位：
Kumamoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670952/
关键词：
attenuation correction SPECT Tl-201 myocardial SPECT scatter image fusion attenuation correction image fusion CT 非対称ファンビームコリメータ 201Tl心筋シンチグラフィ-

项目摘要

Transmission computed tomography (TCT) with external radiation source was conventionally used for attenuation correction (AC). CT is recently used for AC instead of TCT. We evaluated the usefulness of TCT (TCT method) and CT (CT method) for the attenuation correction by a phantom and clinical study. In CT method, we also assessed the clinical usefulness of fused image (AC image with CT).In TCT method, we used a 2-head gamma camera system equipped with asymmetric fan-beam collimator (GCA 7200, Toshiba) and the 3-head gamma camera equipped with fan-beam collimator (Prism 3000, Picker). We introduced a gantry-free gamma camera (SkyLight, ADAC) and multi-detector row CT (Lightspeed ultra, GE) in a same room as a CT/SPECT combined system. In CT method, we used this system.In phantom study using a anthropomorphic phantom, both methods showed improvement in the uniformity of the distribution of Tl-201 in the myocardium. The contrast between the defect and normal myocardium was improved by the scatter correction.In Tl-201 myocardial SPECT, there was the significant difference in specificity between non-corrected (NC) and AC images in the RCA territory and those in specificity and accuracy in the LCX territory. In the LAD territory, there were variable changes in sensitivity and specificity observed on between the AC images and the NC images.Clinical usefulness of fused images was obtained in 84% (50/57) of cancer patients. Useful information on fused images was obtained in the diagnosis of staging and recurrence, differentiation of malignant from benign, and differentiation of pathological from physiological accumulation.TCT method is useful for the attenuation correction on Tl-201 myocardial SPECT. Fused image made by CT method is useful for the nuclear studies of patients with cancer.

具有外部辐射源的透射计算机断层扫描（TCT）通常用于衰减校正（AC）。最近AC使用CT代替TCT。我们通过模型和临床研究评估了TCT（TCT法）和CT（CT法）对于衰减校正的有用性。在CT方法中，我们还评估了融合图像（CT的AC图像）的临床实用性。在TCT方法中，我们使用配备非对称扇形束准直器的2头伽玛相机系统（GCA 7200，东芝）和配备扇形束准直器的3头伽玛相机系统（Prism 3000，Picker）。我们在同一房间内引入了无机架伽马相机（SkyLight，ADAC）和多探测器行 CT（Lightspeed ultra，GE）作为 CT/SPECT 组合系统。在CT方法中，我们使用了该系统。在使用拟人体模的体模研究中，两种方法都显示心肌中Tl-201分布的均匀性有所改善。通过散点校正提高了缺损与正常心肌的对比度。在Tl-201心肌SPECT中，RCA区域的未校正（NC）和AC图像与LCX区域的特异性和准确性存在显着差异。在 LAD 区域，AC 图像和 NC 图像之间观察到的敏感性和特异性存在不同的变化。融合图像的临床实用性在 84% (50/57) 的癌症患者中获得。融合图像为分期和复发的诊断、良恶性的鉴别、病理性与生理性积累的鉴别提供了有用的信息。TCT方法可用于Tl-201心肌SPECT的衰减校正。 CT方法制作的融合图像可用于癌症患者的核研究。