Measurement of fluorine compound (5-FU) in tumor by 19F-MRS.

通过 19F-MRS 测量肿瘤中的氟化合物 (5-FU)。

• 批准号: 07671035
• 负责人: SHIKAURA Satiko
• 金额: $ 1.28万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671035/
• 关键词: 19F-MRS; 5-FU; Experimental tumor; ^<19>F-MRS; 腫瘍; 抗腫瘍効果

In this Study, We measure the chemical shift of 19-Fluorine on FdUMP, FuTP and 5-FU. We obtained 4.9 PPM at 5-FU in experimental mice tumor but it was difficult to separate measurement on FdUMP,FuTP and 5-FU. To obtain the chemical shift, it needs the higher magnetic field system over the 4.7 Tesla. We obtained the calibration curve to measure the 5-FU and 5-FU analogs. At In Vitro. But at In vivo, it was difficult to measure fluorine compound. Because such fluorine compound was very little in experimental mice tumor. And then we can not analyze the F-peak of FdUMP, FuTP and 5-FU.

在本研究中，我们测量了19-氟在FdUMP、FuTP和5-FU上的化学位移。在实验小鼠肿瘤中，我们在5-FU时获得了4.9 PPM，但很难将FdUMP、FuTP和5-FU分开测量。为了获得化学位移，它需要比4.7特斯拉更高的磁场系统。得到了测定5-FU和5-FU类似物的校正曲线。在体外。但在体内，氟化合物的测量是困难的。因为这种氟化合物在实验的小鼠肿瘤中很少。FdUMP、FuTP和5-FU的F峰不能分析。

项目成果

Takashi Murata, Ikuzo Fujii, Masanari Yoshino, Kenji Nagata, Masahiro Imamura, Mitunobu Uda, Keizou Yamamoto, Yoshimasa Tanaka: "Radiation therapy with or without chemotherapy and hyperthermia for recurent rectal cancer"Jpna. Soc. ther. Radiol. Oncol.. 9.

Takashi Murata、Ikuzo Fujii、Masanari Yoshino、Kenji Nagata、Masahiro Imamura、Mitunobu Uda、Keizou Yamamoto、Yoshimasa Tanaka：“复发性直肠癌联合或不联合化疗和热疗的放射治疗”Jpna。

Sachiko Shikaura, Tamaki Asakura, Yoshimasa Tanaka: "Idiopathic Epidural Lipomatosis : A case report"Japanese Journal of dianostic imaging. 17. 986-989 (1997)

Sachiko Shikaura、Tamaki Asakura、Yoshimasa Tanaka：“特发性硬膜外脂肪瘤：病例报告”日本诊断成像杂志。

Murata T, Uda M, Nagata K, Akai M, Imamura M, Tanaka Y, Yoshida J, Takada H, Hioki K, Okamura A: "A case of advanced rectal carcinoma with complete tumor necrosis in combination therapy with low dose radiation and 5-Dexy-5-fluorouridine"Jpn.Cancer clin..

Murata T, Uda M, Nagata K, Akai M, Imamura M, Tanaka Y, Yoshida J, Takada H, Hioki K, Okamura A：“低剂量放射线和 5 联合治疗导致肿瘤完全坏死的晚期直肠癌一例

村田貴史: "直腸癌術後再発の放射線治療-併用治療の有効性の検討"日本放射線腫瘍学会誌. 9. 63-71 (1997)

Takashi Murata：“直肠癌术后复发的放射治疗 - 联合治疗的有效性检查”日本放射肿瘤学会杂志 9. 63-71 (1997)。

村田貴史: "5'-DFURと放射線治療の併用により組織学的に完全壊死"癌の臨終. 42. 1164-1168 (1996)

Takashi Murata：“5-DFUR 和放射治疗相结合导致完全组织学坏死”《癌症之死》42. 1164-1168 (1996)。