Efficacy of Vitamin B12 administration treatment for biological rhythm disorder in the totally blind person

维生素B12给药治疗全盲人生物节律紊乱的疗效

• 批准号: 07671058
• 负责人: NAKAGAWA Hiroki
• 金额: $ 0.9万
• 依托单位: Fukui medical school
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671058/
• 关键词: Total blind person; Sleep-Wake disorder; Circadian rhythm; Vitamin B12; Melatonin; Sleep disorder

In previous studies, most total blind person maintain a roughly 24-hour sleep-wake schedule, even when their other rhythms (melatonin, temperature and so on) are free-running.How many do total blind person complain sleep-wake schdule disorder. I conducted a sleep questionnaire survey of sight handicapped person who were entering the same institution. The subjects were 216,84 of whom were total blind person and 132 were not total blind person. There was not significant difference in rate of prevalent sleep-wake schedule disorders among the total blind and the not total blind. Sleep-wake schedule problem dose not typically bring totally blind person to a physician, because most total blind person have strong information time cues (social cues) and homeostatic mechanisms.Vitamin B12 (VB12) in effective for delayd sleep phase syndrome and non-24-hour sleep-wake syndrome. I administered VB12 to a total blind patient suffering for many years from irregular sleep-wake pattern. Shortly thereafter, her irregular sleep-wake pattern has improved, her total sleep time has increased and her number of awaking has decreased. Her melatonin level in the serum showed low level (under 10pg/ml) during all day before administration of VB12.8 days after administration, her melatonin level has increased up to 20 pg/ml during the night. These results suggest that melatonin level may increased as the result of improvement in irregular pattern by VB12.

在之前的研究中，大多数全盲人维持着大约24小时的睡眠-觉醒时间表，即使他们的其他节律（褪黑激素、体温等）是自由运行的。有多少全盲人抱怨睡眠-觉醒时间表紊乱。我对进入同一机构的视力障碍者进行了睡眠问卷调查。受试者为 216,84 名全盲者，132 名非全盲者。全盲者和非全盲者的睡眠-觉醒时间表紊乱患病率没有显着差异。睡眠-觉醒时间表问题通常不会让全盲人去看医生，因为大多数全盲人都有很强的信息时间线索（社交线索）和稳态机制。维生素 B12 (VB12) 对延迟睡眠综合症和非 24 小时睡眠-觉醒综合症有效。我给一位患有多年不规则睡眠-觉醒模式的完全失明患者服用了VB12。此后不久，她不规律的睡眠-觉醒模式得到改善，总睡眠时间增加，醒来次数减少。在服用VB12之前，她的血清中褪黑激素水平全天呈低水平（低于10pg/ml）。给药后8天，她的褪黑激素水平在夜间增加至20pg/ml。这些结果表明，褪黑激素水平可能因 VB12 改善不规则模式而增加。