Efficacy of Vitamin B12 administration treatment for biological rhythm disorder in the totally blind person

在之前的研究中，大多数完全失明的人保持着大约24小时的睡眠-醒来时间表，即使他们的其他节奏(褪黑激素、体温等)是自由运行的。有多少完全失明的人抱怨睡眠-觉醒时间表紊乱。我对进入同一机构的视障人士进行了睡眠问卷调查。受试者216人，其中84人为全盲，132人为非全盲。全盲组与非全盲组睡眠-觉醒节律紊乱发生率无显著差异。睡眠-醒来时间表问题通常不会让完全失明的人去看医生，因为大多数完全失明的人都有很强的信息时间线索(社交线索)和动态平衡机制。维生素B12(VB12)对睡眠延迟综合征和非24小时睡眠-醒来综合征有效。我给一位患有睡眠-觉醒模式紊乱多年的完全失明患者注射了维生素B12。此后不久，她的不规律睡眠-觉醒模式得到改善，总睡眠时间增加，醒来次数减少。静脉注射维生素B12.8天后，血清褪黑素水平一直较低(<10pg/ml)，夜间褪黑激素水平升高至20pg/ml。这些结果提示，VB12可能通过改善不规则形态而使褪黑激素水平升高。

In previous studies, most total blind person maintain a roughly 24-hour sleep-wake schedule, even when their other rhythms (melatonin, temperature and so on) are free-running.How many do total blind person complain sleep-wake schdule disorder. I conducted a sleep questionnaire survey of sight handicapped person who were entering the same institution. The subjects were 216,84 of whom were total blind person and 132 were not total blind person. There was not significant difference in rate of prevalent sleep-wake schedule disorders among the total blind and the not total blind. Sleep-wake schedule problem dose not typically bring totally blind person to a physician, because most total blind person have strong information time cues (social cues) and homeostatic mechanisms.Vitamin B12 (VB12) in effective for delayd sleep phase syndrome and non-24-hour sleep-wake syndrome. I administered VB12 to a total blind patient suffering for many years from irregular sleep-wake pattern. Shortly thereafter, her irregular sleep-wake pattern has improved, her total sleep time has increased and her number of awaking has decreased. Her melatonin level in the serum showed low level (under 10pg/ml) during all day before administration of VB12.8 days after administration, her melatonin level has increased up to 20 pg/ml during the night. These results suggest that melatonin level may increased as the result of improvement in irregular pattern by VB12.