Effect of inhalational anesthetics on respiratory mechanics ; Bioengineering and mathematical modelling.

吸入麻醉剂对呼吸力学的影响；

• 批准号: 07671644
• 负责人: SATO Jiro
• 金额: $ 1.6万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671644/
• 关键词: inhalational anesthetics; respiratory mechanics; respiratory impedance; ventilation inhomogeneity; resistance; posture; venous return; 不均一換気; 閉塞性肺疾患

We studied the respiratory mechanics in anaesthetic aspects. We used measured alveolar pressures directly which enabled the direct partition of lung into airway and parenchymal components. We also employed the respiratory impedance measurement by a random noise forced oscillation and the mathematical modelling on it. The technique enables indirect stratification of respiratory system into airway, lung parechyma, and chest wall components from the measurements of airway flow and airway opening pressure only. It is applied easily in clinical anesthesia.1. Halothane reduces airway resistance but does not change parencymal property of the normal canine lung.2. Inhalational anaesthetics reduce nonhomogeneous ventilation preferentially to lung resistance in the canine bronchial asthma model.3. We examined the effect of change in intrathoracic blood volume created by altering blood pool in lower extremities in humans. The change in intrathoracic blood volume affects the lung mechanics by altering airway resistance by 10-15%. It does not change the lung parechmal mechanics.4. Body posture changes the lung mechanics in humans. The airway resistance is the highest in supine, the lowest in sitting, and in-between in lateral and prone position. The effect of posture on lung tissue and chest wall is minimal.

我们研究了麻醉方面的呼吸力学。我们直接使用测量的肺泡压力，这使得肺直接划分为气道和实质成分。我们还采用随机噪声强迫振荡法测量呼吸阻抗，并对其进行了数学建模。该技术仅通过测量气道流量和气道开口压力，就可以间接地将呼吸系统分层为气道、肺实质和胸壁成分。它易于应用于临床麻醉。氟烷降低气道阻力，但不改变正常犬肺实质性质。在犬支气管哮喘模型中，吸入麻醉剂减少非均匀通气优先于肺阻力。我们研究了通过改变人类下肢血库而产生的胸内血容量变化的影响。胸内血容量的变化通过改变10-15%的气道阻力影响肺力学。它不改变肺实质机制。身体姿势会改变人体的肺力学。平卧位时气道阻力最大，坐位时最低，侧卧位和俯卧位居中。体位对肺组织和胸壁的影响很小。

项目成果

Norihiro Shinozuka,Jiro Sato Akira Kohchi,et.al.: "Pendel-luft is not the major contributor to respiratory insufficiency in dogs with flail chest : a mathematical anelysis" Journal of Anesthesia. 9(3). 252-259 (1995)

Norihiro Shinozuka、Jiro Sato Akira Kohchi 等人：“Pendel-luft 并不是连枷胸犬呼吸功能不全的主要原因：数学分析”《麻醉杂志》。

J.Sato,N.Shinozuka,A.Kochi,H.Uchida,T.Mizuguchi: "Low-dose halothane produces airway dilatation but does not atter parenchymal mechanics in the normal canine lung" Canadian Journal of Anaeschesia. 44. 438-445 (1995)

J.Sato、N.Shinozuka、A.Kochi、H.Uchida、T.Mizuguchi：“低剂量氟烷产生气道扩张，但不会影响正常犬肺的实质力学”《加拿大麻醉杂志》。

J.Sato,N.Shinozuka,A.Kohchi H.Uchida,T.Mizuguchi: "Low-dose halochane prodvies airway dilatation but does net alter parenchymicl mechanics in the normal canine lung." Canadian Journal of Anaesthesia. 42(5). 438-445 (1995)

J.Sato、N.Shinozuka、A.Kohchi H.Uchida、T.Mizuguchi：“低剂量卤烷会导致气道扩张，但会改变正常犬肺的实质力学。”

Jiro Sato,Rie Kato Norihiro Shinozuka Tadanobu Mizuguchi: "Measuring time-varying respiratory mechanics during aneschesia" Journal of Anesthesia. 9. 151-157 (1995)

佐藤二郎、加藤理惠、筱冢忠信：“测量麻醉期间随时间变化的呼吸力学”麻醉杂志。

J.Sato, N.Shinozuka, A.Kochi, H.Uchida, T.Mizuguchi: "Low-dose halothane produces airway dilatation but does not alter parenchymal mechanics in the normal canine lung." Canadian Journal of Anaesthesia. vol.42. 438-445 (1995)

J.Sato、N.Shinozuka、A.Kochi、H.Uchida、T.Mizuguchi：“低剂量氟烷会导致气道扩张，但不会改变正常犬肺的实质力学。”