Cerbral blood flow dynamics during anesthesia assessed by systems theory.

通过系统理论评估麻醉期间的脑血流动力学。

• 批准号: 09671540
• 负责人: SATO Jiro
• 金额: $ 1.79万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671540/
• 关键词: nitrous oxide; carbon dioxide; dynamic cerebrovascular respons; mathematical model; transcranial Doppler ultrasonography; propofol; 数理モデル; 脳血流; 炭酸ガス負荷

We studied the effect of N_2O on the dynamic cerebrovascular response to changes in end-tidal CO_2 tension (PETCO_2) in healthy humans. By use of a transcranial Doppler ultrasonography, blood flow velocity in the middle cerebral artery (_VMCA) was measured during a step increase followed by a step decrease in PETCO_2 between normo- and hypercapnia while subjects inspired gas mixtures containing 70% O_2 + 30% N_2 (control) and 70% 0_2+30% N_2O (N_2O) separately. In control gas breathing, both step increase and decrease in PETCO_2 produced rapid exponential changes in ^VMCA.An increase in _VMCA produced by the step increase in PETCO_2 was smaller (P < 0.001) and slower (P < 0.001) than a decrease in _VMCA induced by the step decrease in PETCO_2. These general features of the dynamic cerebrovascular response were not affected by N_2O gas breathing although N_2O increased baseline ^VMCA by 15% (P (0.001) compared with control gas breathing. We conclude that N_2O in itself does not affect the dynamic cerebrovascular response to arterial CO_2 changes although N_2O produces static mild cerebral vasodilation. We also examine the effect of propofol on the cerebrovascular dynamic response to PETCO2. When added to N_2O, propofol produced the baseline cerebral vaso constriction. Propofol blunted the dynamic cerebrovascular response to changes in PETCO2.

本文研究了N_2O对正常人呼气末CO_2压力（PETCO_2）变化引起的脑血管动态反应的影响。应用经颅多普勒超声技术，分别测定了正常和高碳酸血症患者吸入70%O_2 + 30%N_2（对照组）和70%O_2 + 30%N_2O（N_2O）混合气体时，PETCO_2阶跃升高和阶跃降低过程中大脑中动脉血流速度（_VMCA）的变化。在控制气体呼吸时，PETCO_2的阶跃增加和降低均引起_VMCA的快速指数变化，由PETCO_2阶跃增加引起的_VMCA的增加比由PETCO_2阶跃降低引起的_VMCA的降低小（P <0.001）和慢（P < 0.001）。N_2O气体呼吸对脑血管动态反应的这些一般特征没有影响，尽管与对照气体呼吸相比，N_2O使基线VMCA增加了15%（P（0.001））。我们的结论是，尽管N_2O产生静态的轻度脑血管舒张作用，但N_2O本身并不影响脑血管对动脉CO_2变化的动态反应。我们还研究了异丙酚对PETCO2脑血管动力学反应的影响。当加入N_2O时，异丙酚产生基线脑血管收缩。异丙酚减弱了对PETCO2变化的动态脑血管反应。

项目成果

青野光夫: "超低体温下循環停止および脳分離体外循環時の脳酸素化・潅流モニターとしての局所脳内酸素飽和序の連続測定" 麻酔. 47. 335-340 (1998)

Mitsuo Aono：“连续测量局部脑氧饱和度，作为低温停循环和脑隔离期间体外循环期间脑氧合和灌注的监测器” 麻醉 47. 335-340 (1998)。

青野光夫: "超低体温下循環停止および脳分離体外循環時の脳酸素化・灌流モニターとしての局所脳内酸素飽和度の連続測定" 麻酔. 47. 335-340 (1998)

Mitsuo Aono：“在低温和离体脑体外循环下循环停止期间连续测量局部脑氧饱和度作为脑氧合和灌注的监测器” 麻醉 47. 335-340 (1998)。

M.Aono, J.Sato, T.Nishino: "Regional Cerebral Oxygen Saturation as a monitor of cerebral oxygenation and perfusion during deep hypothermic circulatory arrest and selective cerebral perfusion." Jpn J Anesth.vol.47. 335-340 (1998)

M.Aono、J.Sato、T.Nishino：“区域脑氧饱和度作为深低温停循环和选择性脑灌注期间脑氧合和灌注的监测器。”