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Pathogenesis of peritoneal dissemination

腹膜播散的发病机制

基本信息

批准号：
07671838
负责人：
KATO Tomoyasu
金额：
$ 1.41万
依托单位：
Japanese Foundation for Cancer Research
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

项目摘要

In order to clarify the mechanisms to explain of production of peritoneal dissemination, the following studies were perfomed.1. Post-operative peritoneal washing cytology in cases of endometrial carcinoma with positive peritoneal cytology. In order to assess the potential of malignant cells in the petitoneal cavity to metastasize, post-operative peritoneal cytology was undertaken. In 12 cases with endometrioid adenocarcinoma and intra-operative positive peritoneal cytology, a Silascon tube was indwelt in the abdominal cavity before closure of the abdomen. The peritoneal cavity was washed with saline 14 days after operation. The cytology of recovered washing was negative in all cases.2. Role of integrin on access of endometrial cancer cells into the pelvic cavity via the fallopian tube. I investigated the relationship between the expression of integrin and cases which had both superficial myometrial invasion and no lymph node metastasis and peritoneal positive cytologh. I showed that all four cases with histological grade 2 had the expression of beta3 integrin.3. Role of integrin on endometrial cancer metastasis to adnexa.I showed the significant relationshipm between the expression of beta1 integrin and adnexal metastasis (p<0.001).4. Risk of peritoneal dissemination in endmerial cancer or gastric cancer.I investigated the risk of peritoneal disseminataion in endometrial cancer and gastric cancer metastasis to ovary. I showed that the risk of peritoneal dissemination was lymph node metastasis rather than malignant cells in pelvic cavity.The above studies demonstrated that malignant cells in the peritoneal cavity appear to have a very low potential fora implantation into the peritoneum.

为了阐明腹膜播散产生的机制，进行了以下研究.子宫内膜癌术后腹腔冲洗细胞学检查。为了评估腹膜腔内恶性细胞转移的可能性，进行了术后腹膜细胞学检查。对12例术中腹腔细胞学检查阳性的卵巢样腺癌患者，在关腹前腹腔内留置Silascon管。术后14天用生理盐水冲洗腹腔。所有病例的回收洗液细胞学检查均为阴性.整合素在子宫内膜癌细胞经输卵管进入盆腔中的作用。本研究探讨了整合素表达与既有浅表肌层浸润又无淋巴结转移、腹膜细胞学阳性病例的关系。结果显示，组织学分级为2级的4例患者均表达β 3整合素.整合素在子宫内膜癌附件转移中的作用：β 1整合素的表达与附件转移有显著相关性（p<0.001）.子宫内膜癌或胃癌腹膜播散的风险：我研究了子宫内膜癌和胃癌转移到卵巢的腹膜播散风险。我认为腹膜转移的危险是淋巴结转移，而不是盆腔内的恶性细胞，上述研究表明，腹膜内的恶性细胞似乎有很低的可能性植入腹膜。