Analysis of factors involved in development of Japanese cedar pollinasis

对日本千叶县丸山区292名11-15岁学龄儿童和1554名成人进行了调查，分析了影响日本雪松花粉症（JCPS）特异性血清IgE阳性者发生JCPS的因素。1995年，JCP特异性IgE在学龄儿童中的阳性率为44.9%，在20-40岁青壮年中上升到66.0%，50岁以后急剧下降，JCP抗体阳性的学龄儿童中JCP的阳性率为41.2%，在20-40岁青壮年中上升到59.5%。JCPS的发生与JCP特异性IgE滴度密切相关。然而，在15岁以下的学龄儿童中，只有62.5%的人表现出最高的CAP RAST滴度（6分），观察到JCPS的发展。而在20岁以上IgE阳性的成人中，JCPS的发生率为92.2%。年龄是血清IgE阳性儿童发生高反应性症状的因素之一。1995年千叶县的JCP花粉量是1994年和1996年的40倍。1996年：对1995年登记的292名学龄儿童中的135名进行了血清IgE水平变化与JCPS高反应性症状的关系的再评价。1995年出现高反应症状的36名学龄儿童，除3名儿童IgE水平升高外，其余均继续出现高反应症状，16名儿童在1996年开始出现高反应症状，尽管JCP计数明显下降，IgE水平稳定或下降。JCP家族3代阳性史及常年性鼻变态反应的发生对JCP特异性IgE阳性者的JCP发生有显著促进作用。8.9%的JCPS患者出现JCPS的自然生长，尤其是在高龄和无家族史的患者中。

The study was performed in 292 school children aged 11-15 and 1554 adults in Maruyama District in Chiba prefecture to analyze the factors which affect development of Japanese cedar pollinosis (JCPS) in JCP specific serum IgE positive subjects. In 1995 incidence of positive JCP specific serum IgE was 44.9% in school children which increased to 66.0% in young adults aged 20-40, and decreased abruptly in subjects after 50 years old.Incidence of JCPS amoug school children with positive JCP serum antibody was 41.2% which increased to 59.5% in young adults aged 20-40. Development of JCPS was closely related to JCP specific IgE titer. However, development of JCPS was observed in only 62.5% of those who showed highest CAP RAST titer (score 6) in school children under 15. On the contrary JCPS developed in 92.2% of IgE positive adults above 20 years old. Aging is one of the factors which facilitate development of hyperreactive symptoms in serum IgE positive children. In 1995 amount of JCP pollen in Chiba prefecture was 40 times as large as those in 1994 and 1996. In 1996 : 135 out of 292 school children who were registered in 1995 were reevaluated as regards relationship between changes of serum IgE levels and those of hyperreactive JCPS symptoms. All of 36 school children who developed hyperreactive symptoms in 1995 continued to show hyperreactive symptoms and 16 children started to show symptoms in 1996 inspite of marked decrease of JCP counts and stable or decreased IgE level except in 3 children who showed increase of IgE level. Positive family history of JCPS in 3 generations and involvement of perennial nasal allergy facilitated significantly development of JCPS in JCP specific IgE positive subjects. Natural grow-out of JCPS was observed in 8.9% of those with JCPS.Natural grow-out was observed particulary in those who developed JCPS in elder age and those without family history of JCPS.