权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Analysis of factors involved in development of Japanese cedar pollinasis

日本柳杉花粉病发生的影响因素分析

基本信息

批准号：
07671841
负责人：
NUMATA Tsutomu
金额：
$ 1.47万
依托单位：
Chiba University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

项目摘要

The study was performed in 292 school children aged 11-15 and 1554 adults in Maruyama District in Chiba prefecture to analyze the factors which affect development of Japanese cedar pollinosis (JCPS) in JCP specific serum IgE positive subjects. In 1995 incidence of positive JCP specific serum IgE was 44.9% in school children which increased to 66.0% in young adults aged 20-40, and decreased abruptly in subjects after 50 years old.Incidence of JCPS amoug school children with positive JCP serum antibody was 41.2% which increased to 59.5% in young adults aged 20-40. Development of JCPS was closely related to JCP specific IgE titer. However, development of JCPS was observed in only 62.5% of those who showed highest CAP RAST titer (score 6) in school children under 15. On the contrary JCPS developed in 92.2% of IgE positive adults above 20 years old. Aging is one of the factors which facilitate development of hyperreactive symptoms in serum IgE positive children. In 1995 amount of JCP pollen in Chiba prefecture was 40 times as large as those in 1994 and 1996. In 1996 : 135 out of 292 school children who were registered in 1995 were reevaluated as regards relationship between changes of serum IgE levels and those of hyperreactive JCPS symptoms. All of 36 school children who developed hyperreactive symptoms in 1995 continued to show hyperreactive symptoms and 16 children started to show symptoms in 1996 inspite of marked decrease of JCP counts and stable or decreased IgE level except in 3 children who showed increase of IgE level. Positive family history of JCPS in 3 generations and involvement of perennial nasal allergy facilitated significantly development of JCPS in JCP specific IgE positive subjects. Natural grow-out of JCPS was observed in 8.9% of those with JCPS.Natural grow-out was observed particulary in those who developed JCPS in elder age and those without family history of JCPS.

本研究以千叶县丸山区292名11~15岁学龄儿童和1554名成人为研究对象，分析了日本雪松花粉症(JCPS)血清特异性IgE阳性者发病的影响因素。1995年学龄儿童JCP特异性IgE阳性率为44.9%，20~40岁青壮年为66.0%，50岁后急剧下降；JCP抗体阳性学龄儿童为41.2%，20~40岁青壮年为59.5%。JCPS的发生与JCP特异性IgE滴度密切相关。然而，在15岁以下的学龄儿童中，CAP RAST滴度最高(6分)的儿童中只有62.5%的人发生了JCPS，而在20岁以上的IgE阳性的成年人中，92.2%的人发生了JCPS。年龄是促使血清IgE阳性儿童出现高反应性症状的因素之一。1995年，千叶县的JCP花粉量是1994年和1996年的40倍。1996年：对1995年登记的292名学龄儿童中的135名重新评估了血清IgE水平变化与JCPS高反应性症状之间的关系。1995年出现高反应性症状的36名学龄儿童全部继续出现高反应性症状，16名儿童在1996年开始出现症状，但JCP计数明显减少，除3名儿童IgE水平升高外，其余均稳定或下降。JCP特异性IgE阳性者有3代JCPS阳性家族史和常年性鼻变态反应，可显著促进JCPS的发生。JCPS的自然生长发生率为8.9%，尤以老年JCPS患者和无JCPS家族史的患者为甚。