Prevent and therapeutic strategy bycombination of microarray and proteomics for seasonal allergic rhinitis caused by Japanese cedar pollen.

日本60%的成年人有日本雪松花粉（JCP）特异性IgE。 日本成人中由JCP（AR-JCP）引起的过敏性鼻炎（AR）的患病率为40%。本研究通过全基因组关联研究AR-JCP相关基因，并通过基因芯片和蛋白质组分析研究AR-JCP相关基因表达。我们发现ORMDL-3、CST-1、IL-33、Allergin-1和载脂蛋白A4与AR-JCP的发病相关。还发现几个SNP与AR-JCP相关。

Sixty percent of adult in Japan have Japanese cedar pollen (JCP)-specific IgE. Prevalence of allergic rhinitis (AR) caused by JCP (AR-JCP) in Japanese adults is 40%. In this study we investigated AR-JCP-related gene by genome wide associated study, and gene expression by microarray and proteome analysis. We found that ORMDL-3, CST-1, IL-33, Allergin-1, and Apolipoprotein A4 are associated with onset of AR-JCP. Several SNP are also found to be associated with AR-JCP.