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Retinal toxicity of vitreous substitutes used in the difficult retinal detachment surger.

用于困难视网膜脱离手术的玻璃体替代物的视网膜毒性。

基本信息

批准号：
07671912
负责人：
DOI Motoaki
金额：
$ 1.47万
依托单位：
Mie University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

项目摘要

Silicone oil, fluorosilicone oil, silicone/fluorosilicone copolymer oil, and perfluorocarbon liquids are useful as operative tools or retinal tamponades in vitreous surgery to treat difficult retinal detachement. Sulfur hexafluoride gas and perfluoropropane gas also are used as retinal tamponades. The use of silicone/fluorosilicone copolymer oil, which was a higher denstity than water and relatively low viscosity, resulted in the disappearance of the outer plexiform layr of the inferior retina 2 months after the oil was injected into the rabbit vitreous cabity. In the experiment, abnormalities of the photoreceptor layr in the inferior retina and small droplets digested by mononuclear cells in the rabbit vitreous cavity or preretina were found after 2 months in eyes injected with silicone/fluorosilicon copolymer oil. Furthemore, silicone/fluorosilicone copolymer oil-soluble antiproliferative drugs, such as retinoic acid, reduced the occurrence of proliferative vitreoretinopathy formation. Thinning or disappearance of the outer plexiform layr and abnormalities of the photoreceptor layr in the rabbit inferior retina were observed after eyes were injected with fluorosilicone oil, which has a higher density than water and high viscosity. Although the cause of visual field loss is unknown after human vitreous surgery with fluid/gas exchange to treat idiopathic macular hole or remove subretinal choroidal neovascular membranes, a possible cause may be the effects of intraocular gas tamponade. In the present study, histopathologically and histocytochemically abnormal findings were observed in the superior retina after perfluoropropane gas and sulfur hexafluoride gas wers injected into the rabbit vitreous cavity.

硅油、氟硅油、硅/氟硅共聚物油和全氟碳液体在玻璃体手术中可用作手术工具或视网膜填塞治疗难治性视网膜脱离。六氟化硫气体和全氟丙烷气体也可用作视网膜填塞剂。使用密度比水高、粘度相对较低的有机硅/氟有机硅共聚物油，在兔玻璃体内注射2个月后，下视网膜外丛状层消失。实验中，注射硅/氟硅共聚物油2个月后，兔下视网膜感光层出现异常，玻璃体腔或视网膜内单个核细胞消化小液滴。此外，有机硅/氟有机硅共聚物油溶性抗增殖性药物，如维甲酸，可减少增殖性玻璃体视网膜病变形成的发生。氟硅油具有比水高的密度和高粘度，经眼内注射后，兔下视网膜外丛状层变薄或消失，光感受器层异常。虽然在人类玻璃体手术中进行液/气交换治疗特发性黄斑孔或去除视网膜下脉络膜新生血管膜后，视野丧失的原因尚不清楚，但一个可能的原因可能是眼内气体填塞的影响。本研究在兔玻璃体腔内注射全氟丙烷气体和六氟化硫气体后，观察到上视网膜的组织病理学和组织细胞化学异常。