Search for the salivary proline-rich peptide P-B related genes

寻找唾液富含脯氨酸肽P-B相关基因

• 批准号: 07672034
• 负责人: ISEMURA Satoko
• 金额: $ 0.96万
• 依托单位: Nippon Dental University Junior College at Niigata
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672034/
• 关键词: saliva; salivary gland; proline-rich protein; human gene; P-B; P-B1; PBI; 顎下腺; 高プロリン蛋白質; 遺伝子; 高プロリン含有ペプチド; P‐B

The nucleotide sequence of gene PBI,a putativetranslational product of which is homologous to salivary prolin-rich protein P-B has been determined. PBI is 6.4kb long and contains 3 exons. The present result indicates that PBI is capable of coding for the precursor of proline-rich protein which we have designated P-B1. The P-B1 precursor is composed of 134 amino acid residues including 22 residues of signal sequence, 23 residues of N-terminal sequence, five repeating units of 13 to 14 residues and 22 residues of C-terminal sequence. The signal sequence of this precursor is identical with that of the P-b precursor. The N-terminal 61 residue sequence of P-B1 has homology of 75% as compared with the whole sequence of P-B (57 residues), when deletion of 4 residues is taken into account. P-B1 is 55 residues longer than P-B.

PBI基因的核苷酸序列已被测定，推测其翻译产物与唾液富含脯氨酸蛋白P-B同源。PBI全长6.4kb，包含3个外显子。目前的结果表明，PBI是能够编码的前体脯氨酸丰富的蛋白，我们已经命名为P-B1。P-B1前体由134个氨基酸残基组成，包括22个信号序列残基、23个N端序列残基、5个13 - 14残基的重复单元和22个C端序列残基。该前体的信号序列与P-b前体的信号序列相同。P-B1的N端61个残基的序列与P-B的全序列（57个残基）相比，当考虑到4个残基的缺失时，同源性为75%。P-B1比P-B长55个残基。