Genome organizer SATB1 function in salivary gland and development and growth

基因组组织者 SATB1 在唾液腺及其发育和生长中的功能

基本信息

项目摘要

Project Summary/Abstract Salivary glands produce saliva, which facilitates digestion, acts as a lubricant to swallow foods, and prevents infections in oral cavity and tooth decay. Therefore, salivary gland function is important for oral health. Currently, there is no effective treatment for impaired salivary glands, which can be caused by therapeutic irradiation for the head and neck cancer or autoimmune diseases. To develop therapeutic strategies in the future, it is essential to understand the regulatory mechanisms underling development of salivary glands and their regeneration. Little is known about the regulators of gene expression, epigenetics and chromatin organization for salivary glands. Here, we will test a hypothesis that the genome organizer SATB1 is a critical regulator in salivary gland embryonic development, early postnatal growth and development, and function. This hypothesis is supported by SATB1 protein being expressed in both acinar and ductal cells at postnatal day 12 (P12) of wild-type mice and by detection of much smaller salivary glands in Satb1-/- mice compared to wild-type mice. We will identify SATB1 protein-expressing cells in SGs during embryonic and postnatal development. By genetic lineage tracing, we will study the role of SATB1 in acinar cell development and function. We will delete SATB1 in acinar cell- specific cell lineages (e.g. AQPT5+ or MIST1+ cells) at specific time points and determine the effects of SATB1 ablation in their descendants. Through these experiments, we will learn the roles of SATB1 in proliferation, morphogenesis, survival and growth during embryonic and early postnatal development. In addition, combining the lineage-tracing approach with Global run-on sequencing (GRO-seq), which captures nascent transcripts, we will identify genes regulated by SATB1 in a cell lineage-specific and stage-specific manner. We expect that results from these proposed experiments will uncover the critical contribution of SATB1 in salivary gland development, growth and function, and such information will likely provide the foundation for the future therapeutic design to promote salivary gland regeneration.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Terumi Kohwi-Shigematsu其他文献

Terumi Kohwi-Shigematsu的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Terumi Kohwi-Shigematsu', 18)}}的其他基金

Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
  • 批准号:
    9244030
  • 财政年份:
    2014
  • 资助金额:
    $ 24.23万
  • 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
  • 批准号:
    8675078
  • 财政年份:
    2014
  • 资助金额:
    $ 24.23万
  • 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
  • 批准号:
    8865636
  • 财政年份:
    2014
  • 资助金额:
    $ 24.23万
  • 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
  • 批准号:
    9213517
  • 财政年份:
    2014
  • 资助金额:
    $ 24.23万
  • 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
  • 批准号:
    9484083
  • 财政年份:
    2014
  • 资助金额:
    $ 24.23万
  • 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
  • 批准号:
    9043728
  • 财政年份:
    2014
  • 资助金额:
    $ 24.23万
  • 项目类别:
CHARACTERIZATION OF SATB1 MODIFICATIONS FOLLOWING IONIZATION RADIATION
电离辐射后 SATB1 修饰的表征
  • 批准号:
    8170703
  • 财政年份:
    2010
  • 资助金额:
    $ 24.23万
  • 项目类别:
Determinants for genome-wide epigenomics in metastatic breast cancer
转移性乳腺癌全基因组表观基因组学的决定因素
  • 批准号:
    7726410
  • 财政年份:
    2009
  • 资助金额:
    $ 24.23万
  • 项目类别:
Non B DNA Structure with Chemical Carcinogens
含有化学致癌物质的非 B DNA 结构
  • 批准号:
    7909158
  • 财政年份:
    2009
  • 资助金额:
    $ 24.23万
  • 项目类别:
Determinants for genome-wide epigenomics in metastatic breast cancer
转移性乳腺癌全基因组表观基因组学的决定因素
  • 批准号:
    8301480
  • 财政年份:
    2009
  • 资助金额:
    $ 24.23万
  • 项目类别:

相似海外基金

心房細動に対するPulsed Field Ablationの組織創傷治癒過程を明らかにする網羅的研究
阐明房颤脉冲场消融组织伤口愈合过程的综合研究
  • 批准号:
    24K11201
  • 财政年份:
    2024
  • 资助金额:
    $ 24.23万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Targeted ablation of cerebral atherosclerosis using supramolecular self-assembly
利用超分子自组装靶向消融脑动脉粥样硬化
  • 批准号:
    24K21101
  • 财政年份:
    2024
  • 资助金额:
    $ 24.23万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
遅延造影心臓MRIによる心房細動Ablation冷却効果の比較:28 vs. 31 mm Cryoballoon
使用延迟对比增强心脏 MRI 比较房颤消融冷却效果:28 毫米与 31 毫米 Cryoballoon
  • 批准号:
    24K11281
  • 财政年份:
    2024
  • 资助金额:
    $ 24.23万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
InSPACE-VT_Development and Validation of Virtual Pace Mapping to Guide Catheter Ablation of Ventricular Tachycardia
InSPACE-VT_虚拟起搏测绘的开发和验证以指导室性心动过速导管消融
  • 批准号:
    EP/Z001145/1
  • 财政年份:
    2024
  • 资助金额:
    $ 24.23万
  • 项目类别:
    Fellowship
CAREER: Heat Penetration Depth and Direction Control with Closed-Loop Device for Precision Ablation
职业:利用闭环装置控制热穿透深度和方向,实现精确烧蚀
  • 批准号:
    2338890
  • 财政年份:
    2024
  • 资助金额:
    $ 24.23万
  • 项目类别:
    Continuing Grant
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
  • 批准号:
    2334777
  • 财政年份:
    2024
  • 资助金额:
    $ 24.23万
  • 项目类别:
    Continuing Grant
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
  • 批准号:
    2334775
  • 财政年份:
    2024
  • 资助金额:
    $ 24.23万
  • 项目类别:
    Continuing Grant
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
  • 批准号:
    2334776
  • 财政年份:
    2024
  • 资助金额:
    $ 24.23万
  • 项目类别:
    Continuing Grant
MRI: Acquisition of a Laser Ablation - Inductively Coupled Plasma - Triple Quadrupole - Mass Spectrometer (LA-ICP-QQQ-MS) System For Research and Education
MRI:获取用于研究和教育的激光烧蚀 - 电感耦合等离子体 - 三重四极杆 - 质谱仪 (LA-ICP-MS/MS) 系统
  • 批准号:
    2320040
  • 财政年份:
    2023
  • 资助金额:
    $ 24.23万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了