Genome organizer SATB1 function in salivary gland and development and growth
基因组组织者 SATB1 在唾液腺及其发育和生长中的功能
基本信息
- 批准号:10593721
- 负责人:
- 金额:$ 24.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-01-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAblationAcinar CellAdultAmeloblastsArchitectureAtlasesAutoimmune DiseasesBindingBiological ProcessCategoriesCell CycleCell Differentiation processCell LineageCell MaturationCell physiologyCellsCellular StructuresChromatinDataDatabasesDefectDeglutitionDental cariesDetectionDevelopmentDigestionDistalDuctal Epithelial CellEmbryoEmbryonic DevelopmentEpidermisEpigenetic ProcessEpithelial CellsFoodFoundationsFutureGene ExpressionGene Expression ProfileGene Expression RegulationGenesGeneticGenetic RecombinationGenetic TranscriptionGenomeGenomicsGlandGrowthGrowth and Development functionHead and Neck CancerHuman GenomeImpairmentInfection preventionKnockout MiceLearningLinkLocationLubricantsMalignant NeoplasmsMetabolismModelingMorphogenesisMusNational Institute of Dental and Craniofacial ResearchNatural regenerationNormal CellNuclearOral cavityOral healthOrganOsteoblastsPhenotypeProductionProliferatingPropertyProteinsRNARegulator GenesRegulatory T-LymphocyteRoleSalivaSalivary GlandsSamplingSjogren&aposs SyndromeStratum BasaleStructureT-Cell ActivationT-Cell DepletionT-Cell DevelopmentT-LymphocyteT-Lymphocyte SubsetsTestingTherapeuticTimeTissuesTooth structureTranscriptWild Type Mouseaquaporin 5basebody systemcell typecomparison controldesigneffective therapyexperimental studyfetalgenomic locusgland developmentglobal run on sequencingirradiationmouse genomenoveloral infectionpostnatalpostnatal developmentpreventprogenitorprogramsprotein expressionrecruitsatellite cellstem cellsthymocytetissue culturetranscription factortranscriptome sequencing
项目摘要
Project Summary/Abstract
Salivary glands produce saliva, which facilitates digestion, acts as a lubricant to swallow foods, and prevents
infections in oral cavity and tooth decay. Therefore, salivary gland function is important for oral health. Currently,
there is no effective treatment for impaired salivary glands, which can be caused by therapeutic irradiation for
the head and neck cancer or autoimmune diseases. To develop therapeutic strategies in the future, it is essential
to understand the regulatory mechanisms underling development of salivary glands and their regeneration. Little
is known about the regulators of gene expression, epigenetics and chromatin organization for salivary glands.
Here, we will test a hypothesis that the genome organizer SATB1 is a critical regulator in salivary gland
embryonic development, early postnatal growth and development, and function. This hypothesis is supported
by SATB1 protein being expressed in both acinar and ductal cells at postnatal day 12 (P12) of wild-type mice
and by detection of much smaller salivary glands in Satb1-/- mice compared to wild-type mice. We will identify
SATB1 protein-expressing cells in SGs during embryonic and postnatal development. By genetic lineage tracing,
we will study the role of SATB1 in acinar cell development and function. We will delete SATB1 in acinar cell-
specific cell lineages (e.g. AQPT5+ or MIST1+ cells) at specific time points and determine the effects of SATB1
ablation in their descendants. Through these experiments, we will learn the roles of SATB1 in proliferation,
morphogenesis, survival and growth during embryonic and early postnatal development. In addition, combining
the lineage-tracing approach with Global run-on sequencing (GRO-seq), which captures nascent transcripts, we
will identify genes regulated by SATB1 in a cell lineage-specific and stage-specific manner. We expect that
results from these proposed experiments will uncover the critical contribution of SATB1 in salivary gland
development, growth and function, and such information will likely provide the foundation for the future
therapeutic design to promote salivary gland regeneration.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Terumi Kohwi-Shigematsu其他文献
Terumi Kohwi-Shigematsu的其他文献
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{{ truncateString('Terumi Kohwi-Shigematsu', 18)}}的其他基金
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
9244030 - 财政年份:2014
- 资助金额:
$ 24.23万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
8675078 - 财政年份:2014
- 资助金额:
$ 24.23万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
8865636 - 财政年份:2014
- 资助金额:
$ 24.23万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
9213517 - 财政年份:2014
- 资助金额:
$ 24.23万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
9484083 - 财政年份:2014
- 资助金额:
$ 24.23万 - 项目类别:
Benzo[a]pyrene-induced chromatin organization and epigenomics mediated by SATB1
SATB1介导的苯并[a]芘诱导的染色质组织和表观基因组学
- 批准号:
9043728 - 财政年份:2014
- 资助金额:
$ 24.23万 - 项目类别:
CHARACTERIZATION OF SATB1 MODIFICATIONS FOLLOWING IONIZATION RADIATION
电离辐射后 SATB1 修饰的表征
- 批准号:
8170703 - 财政年份:2010
- 资助金额:
$ 24.23万 - 项目类别:
Determinants for genome-wide epigenomics in metastatic breast cancer
转移性乳腺癌全基因组表观基因组学的决定因素
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7726410 - 财政年份:2009
- 资助金额:
$ 24.23万 - 项目类别:
Non B DNA Structure with Chemical Carcinogens
含有化学致癌物质的非 B DNA 结构
- 批准号:
7909158 - 财政年份:2009
- 资助金额:
$ 24.23万 - 项目类别:
Determinants for genome-wide epigenomics in metastatic breast cancer
转移性乳腺癌全基因组表观基因组学的决定因素
- 批准号:
8301480 - 财政年份:2009
- 资助金额:
$ 24.23万 - 项目类别:
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