RESEARCH FOR IMPROVEMENT OF CURATIVE RATE AND LATE EFFECT IN THE TREATMENT OF ORAL CANCER WITH THE USE OF HYPERFRACTIONATED RADIOTHERAPY.

使用超分割放射治疗提高口腔癌治疗率和迟发效果的研究。

• 批准号: 07672046
• 负责人: FUJITA Minoru
• 金额: $ 1.47万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672046/
• 关键词: RADIATION THERAPY; HYPERFRACTIONATION; ORAL CANCER; MALIGNANT TUMOR; SQUAMOUS CELL CARCINOMA; 多分割放射線治療

To estimate the efficacy of hyperfractionated radiotherapy for oral cancer, a clinical trial was conducted. Twenty one patients with previously untreated and biopsy-proven squamous cell carcinoma ofhe oral cavity were entered in this study. Two-year survival rate was high, 66.7% because there were more patients with T1 or T2 tumor than those with T3 or T4 tumor and also because salvage surgery worked well. However, there was not any variable which made a survival rate to improve using hyperfractionated radiotherapy. Local control rate was influenced by the size of tumor. A higher control rate was obtained in the patients with lower stages of tumor, and it was considered from the stad point of organ preservation that a small size of gaingival or buccal carcinoma would be involved in indications for hyperfractionated radiotherapy. On the contrary, a control rate of advanced diseases was the same as that of published data. Modifications of a total dose and a combination of chemotherapy wo … More uld be a subject which should be disclosed as quickly as possible. The grade of acute mucosal reaction was severer than that in the conventional fractionation. It was, however, estimated as tolerable and any split in the treatment was not needed. The incidence of late reactions was low, possibly due to a shorter period of follow-up, but it was suggested that the close management of the whole oral cavity was necessary in the patients.From these findings in the trial, we tried to compare preliminary results between the treatment with hyperfractionated radiotherapy alone and the combined treatment of hyperfracionated radiotherapy and chemotherapy for the development of a clinical management in the future. Local control rates were improved unsuccessfully when hyperfractionated radiotherapy alone was used, but those were improved when chemotherapy was used with a combination of hyperfractionated radiotherapy. Although a clinical advantage of the combination of chemotherapy and a better mode of the combination have not shown yet, we consider that the combination of chemotherapy would be an actual choice to obtain an improvement of therapeutic ratio. Less

为了评估超分割放射治疗口腔癌的疗效，进行了一项临床试验。21例未经治疗并经活检证实的口腔鳞状细胞癌患者进入本研究。由于T1或T2肿瘤患者多于T3或T4肿瘤患者，并且挽救性手术效果良好，因此2年生存率较高，为66.7%。然而，没有任何变量使生存率提高使用超分割放射治疗。肿瘤大小影响局部控制率。肿瘤分期越低，控制率越高。从器官保存的角度考虑，小体积的牙龈癌或颊癌应考虑超分割放疗的适应证。相反，晚期疾病的控制率与公布的数据相同。总剂量和联合化疗的调整， ...更多信息 这是一个应该尽快披露的问题。急性粘膜反应分级较常规分级严重。然而，估计其可耐受，不需要治疗中的任何分割。晚期反应的发生率较低，可能是由于随访时间较短，但提示患者有必要对整个口腔进行密切管理。从试验中的这些发现来看，我们试图比较单纯超分割放射治疗和超分割放射治疗与化疗联合治疗的初步结果，以制定临床治疗方案。未来局部控制率提高不成功时，单独使用超分割放疗，但这些改善化疗与超分割放疗相结合。虽然联合化疗的临床优势和更好的联合模式尚未显示出来，但我们认为联合化疗是提高治疗率的一种实际选择。少

项目成果

藤田實: "Altered fractionation in the radiotheray of oral cancer" Oral Oncology. TV, A. 385-388 (1995)

Minoru Fujita：“口腔癌放射治疗中的改变分割”Oral Oncology TV，A. 385-388 (1995)。