Detection of malignancies of head and neck cancer using PET and change induced by radiation therapy

正电子发射断层扫描（PET）示踪剂2- 18 F-氟-2-脱氧-D-葡萄糖（FDG）是肿瘤学中使用最广泛的示踪剂。本文对17例头颈部恶性肿瘤患者行PET检查，并与MRI、CT及病理结果进行对照分析，评价PET在头颈部恶性肿瘤诊断中的价值。病理结果显示有二例有淋巴结转移。FDG-PET在咽后间隙发现的最小转移淋巴结为4 mm。注射FDG后10 ~ 60 min，转移淋巴结摄取逐渐增加，反应性淋巴结摄取逐渐减少。恶性病变中FDG摄取率似取决于肿瘤细胞与间质的比值。在这个系列中，作者发现FDG-PET是一种有用的诊断模式，用于评估头颈部癌症患者。

The positron emission tomography (PET) tracer 2-18F-fluoro-2-deoxy-D-glucose (FDG) is the most widely used tracer in oncology. This study was undertaken to evaluate PET in the detection of head and neck malignancies, compared to analysis of MRI,CT and histopathological findings.A total of 17 patients with malignant tumors were examined with FDG.PET revealed that each biopsy-proven primary lesion is an area of increased FDG uptake. Metastatic lymph node has been demonstrated in two cases by the pathologic findings. The smallest metastatic lymph node detected in the retropharyngeal space by FDG-PET was 4mm. The uptake of FDG in lymph nodes were studied from 10 to 60 min after a injection of FDG.Metastatic lymph node uptake increased gradually after injection, whereas reactive node uptake decreased. The FDG uptake ratio was seemed depend on the rate between tumor cells and interstitial tissue in malignant lesion. In this series, the authors found that FDG-PET is a useful diagnostic modality for evaluation the patient with head and neck cancers.