Detection of malignancies of head and neck cancer using PET and change induced by radiation therapy

正电子发射断层扫描（PET）示踪剂2- 18f -氟-2-脱氧-d -葡萄糖（FDG）是肿瘤学中应用最广泛的示踪剂。本研究旨在评估PET在头颈部恶性肿瘤检测中的作用，并与MRI、CT和组织病理学结果进行比较。对17例恶性肿瘤患者进行FDG检查。PET显示每个活检证实的原发病变都是FDG摄取增加的区域。转移性淋巴结已证实在两个病例的病理结果。FDG-PET在咽后间隙检测到的最小转移淋巴结为4mm。注射FDG后10 ~ 60分钟，研究FDG在淋巴结的摄取情况。注射后转移性淋巴结摄取逐渐增加，而反应性淋巴结摄取减少。FDG摄取比似乎与肿瘤细胞与间质组织间的比值有关。在本系列中，作者发现FDG-PET是评估头颈癌患者的一种有用的诊断方式。

The positron emission tomography (PET) tracer 2-18F-fluoro-2-deoxy-D-glucose (FDG) is the most widely used tracer in oncology. This study was undertaken to evaluate PET in the detection of head and neck malignancies, compared to analysis of MRI,CT and histopathological findings.A total of 17 patients with malignant tumors were examined with FDG.PET revealed that each biopsy-proven primary lesion is an area of increased FDG uptake. Metastatic lymph node has been demonstrated in two cases by the pathologic findings. The smallest metastatic lymph node detected in the retropharyngeal space by FDG-PET was 4mm. The uptake of FDG in lymph nodes were studied from 10 to 60 min after a injection of FDG.Metastatic lymph node uptake increased gradually after injection, whereas reactive node uptake decreased. The FDG uptake ratio was seemed depend on the rate between tumor cells and interstitial tissue in malignant lesion. In this series, the authors found that FDG-PET is a useful diagnostic modality for evaluation the patient with head and neck cancers.