Fundamental and clinical assessment of F-18 Choline as a new cancer tracer for PET

这项研究评估了胆碱作为一种新的PET癌症示踪剂的潜在用途。摄取[18F]胆碱和[18F]FDG依赖于细胞周期，与PET成像中肿瘤的增殖活性有关。牙周癌浸润性颌骨的平均SUV明显高于舌部。[11&gt；C]或[18&gt；F]胆碱的平均SUV在舌癌和牙龈癌之间没有显著差异，与舌癌的FDG摄取水平相同。胆碱似乎没有很好地结合到与骨代谢有关的成骨细胞和破骨细胞中，而是积聚在癌细胞中。

This study evaluated the potential usefulness of[^<18> F] Choline as a new cancer tracer for PET. The uptake of[^<18> F] Choline and[^<18> F] FDG are cell cycle dependent, are associated with the proliferative activity of the tumor seen during PET imaging. The average SUVs of[^<18> F] FDG for the gingival cancer infiltrated jawbone was markedly higher than that for the tongue. The average SUVs of[^<11> C] or[^<18> F] Choline were showing no significant difference between the tongue and gingival cancer, and the same level as[^<18> F] FDG uptake for the tongue cancer. It seems that[^<18> F] Choline is not well incorporated to the osteogenetic cell and the osteoclast related to bone metabolism but accumulation for the cancer cells.