Effects of Physical Exercise on the Jaw Bones of the Rat at the Growth Stage

体育锻炼对生长期大鼠颌骨的影响

• 批准号: 07672229
• 负责人: KIMURA Mitsutaka
• 金额: $ 1.02万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672229/
• 关键词: Growth stage; Jaw; Physical execise; Bone; Microanalyzer; Histopathological; SEM; Rat

It is considered that inadequate exercise and calcium intake has an influence on bone tissue in growth stage, but no report has been found on the effect of physical exercise and calcium intake on developing jaw.Male Wistar rats of 4-week-old were subjacted to running exercise with different calcium-content feeding for 4 weeks to investigate change of tibia meta-physis, comparing with mandible. Control group : no exercise, with standard diet. Standard 1-exercise : running exercise of 20 m/min, 1h/time/day, 5 times/week. Standard 2-exercise : the way as in 1-exercise group but 2 times/week. Calcium-doficient no-exercise, calcium-deficient 1-exercise, and calcium-doficient 2-exercise group were subjected to the exercise as in standard group, fed with calcium deficient diet. The results were as follows. 1. Mandible 1) Bone density, 2) Ca and P quantitative analysis with microanalyzer, 3) histopathological, 4) SEM,5) compression strength examination did not showed any change deriving from running exercise, considering the developing mandible was subjected to the normal occlusal and masticantory forse. 2. Tibia metaphysis SEM investigation revealed activated development of chondrocyte layr in 2-exercise group fed with standard diet, comparing with those no exercise stress was applied in. The trabeculae was demonstrated more thick, arrangement more regular, and bone mass increased, implying that formation of bone matrix was improved.Considering the above findings, it was concluded that exercise was effective in promoting the bone formation in growth stage.

认为运动和钙摄入不足对生长阶段骨组织有影响，但未见体育锻炼和钙摄入对发育中的颌骨的影响的报道。4周龄雄性Wistar大鼠进行跑步运动，饲喂不同钙含量的饲料4周，观察胫骨骨骺的变化，并与下颌骨进行比较。对照组：不运动，饮食标准。标准1-运动：20米/分钟，1小时/次/天，5次/周的跑步运动。标准2-运动：与1-运动组相同，但每周2次。缺钙不运动组、缺钙1-运动组、缺钙2-运动组与标准组相同运动，饲喂缺钙饮食。结果如下：1. 1)骨密度，2)钙、磷微量分析仪定量分析，3)组织病理学，4)扫描电镜，5)抗压强度检查，考虑到发育中的下颌骨受到正常的咬合和咀嚼力，未见跑步运动引起的变化。2. 胫骨干骺端扫描电镜显示，与未施加运动应激组相比，2-运动组给予标准饮食后，软骨细胞层发育被激活。骨小梁变粗，排列更规则，骨量增加，提示骨基质形成改善。综上所述，运动对生长阶段骨形成具有促进作用。