Study on new biologically active substances isolated from Ascomycetous fungi

从Emericella sp. purpurea中分离到2个新的酯萜类化合物，分别命名为variecolol和variecolic酸，以及3个新的黄色2,3-二氰-1,4-二苯基-1,3-丁二烯衍生物epurpurins A-C和具有抑制血管紧张素II结合活性的酯萜类化合物variecolin。双氰衍生物对L1210细胞有生长抑制作用。从falconensis和（或）fruticulosa的菌丝体中分离到6个新的氢化氮氮素E-G和I-N，以及2个新的具有长共轭体系的色素EF-Y1和EF-Y2。这些鹰凝素对肿瘤启动子具有抑制活性。从异菌E.heterothallica培养基中分离到对烟曲霉具有较强抗真菌活性的新18,22-环甾醇、酯甾醇B、酯甾醇C和酯甾醇A。从叶黄菌培养液中分离到一种新的表皮硫代二氧哌嗪，从桃金猴的子囊层中分离到一种氮唑酮和一种氢化蒽醌二聚体。此外，还从虫体中分离到了氢化氮唑啉衍生物和蒽醌二聚体天青苷。从美洲岩霉菌的子囊基质中分离到4个新的双吲哚苯衍生物petromurin a - d、一种双吲哚苯醌Pm-53和一种吲哚萜类化合物petromindole。

The following compounds were isolated from Emericella sp. From E.purpurea, two new sesterterpenes designated variecolol and variecolic acid and three new yellow 2,3-dicyano-1,4-diphenyl-1,3-butadiene derivatives, epurpurins A-C,were isolated along with the sesterterpene, variecolin, which has angiotensin II binding inhibitory activity. The dicyanide derivatives had the growth inhibitory activity for L1210 cells. Six new hydrogenated azaphilones, falconensin E-G and I-N,and two new pigments with a long conjugated system, EF-Y1 and EF-Y2, were isolated along with the azaphilones from the mycelium of E.falconensis and/or E.fruticulosa. These falconensins will be expected the inhibitory activity for tumor promotor. From the culture medium of E.heterothallica, new 18,22-cyclosterols, emesterols B and C,were isolated along with emesterol A,which had the strong antifungal activty against Aspergillus fumigatus. A new epitetrathiodioxopiperazine, secoemestrin C,was isolated from the early stage of the culture broth of E.foveolata.From the ascostromata of Talaromyces austrocalifornicus, an azaphilone and a hydrogenated anthraquinone dimer was isolated. A hydroganated azaphilone derivatives and an anthraquinone dimer, skyrin, were also isolated from T.wortmanni. From the ascostromata of Petromyces muricans, four new bisindolylbenzene derivatives, petromurin A-D,a bisindolylbenzoquine (asteriiquinone), Pm-53, and an indoloditerpene, petromindole, were isolated.