Study on new biologically active substances isolated from Ascomycetous fungi

子囊菌新生物活性物质的研究

• 批准号: 07672296
• 负责人: KAWAI Kenichi
• 金额: $ 1.41万
• 依托单位: Hoshi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672296/
• 关键词: Ascomycetous fungi; Fungal metabolites; Emericella sp.; Talaromyces sp.; Petromyces sp.; Indoloditerpene; Azaphilone; Dicyanide derivatives

The following compounds were isolated from Emericella sp. From E.purpurea, two new sesterterpenes designated variecolol and variecolic acid and three new yellow 2,3-dicyano-1,4-diphenyl-1,3-butadiene derivatives, epurpurins A-C,were isolated along with the sesterterpene, variecolin, which has angiotensin II binding inhibitory activity. The dicyanide derivatives had the growth inhibitory activity for L1210 cells. Six new hydrogenated azaphilones, falconensin E-G and I-N,and two new pigments with a long conjugated system, EF-Y1 and EF-Y2, were isolated along with the azaphilones from the mycelium of E.falconensis and/or E.fruticulosa. These falconensins will be expected the inhibitory activity for tumor promotor. From the culture medium of E.heterothallica, new 18,22-cyclosterols, emesterols B and C,were isolated along with emesterol A,which had the strong antifungal activty against Aspergillus fumigatus. A new epitetrathiodioxopiperazine, secoemestrin C,was isolated from the early stage of the culture broth of E.foveolata.From the ascostromata of Talaromyces austrocalifornicus, an azaphilone and a hydrogenated anthraquinone dimer was isolated. A hydroganated azaphilone derivatives and an anthraquinone dimer, skyrin, were also isolated from T.wortmanni. From the ascostromata of Petromyces muricans, four new bisindolylbenzene derivatives, petromurin A-D,a bisindolylbenzoquine (asteriiquinone), Pm-53, and an indoloditerpene, petromindole, were isolated.

从 Emericella sp. 中分离出以下化合物。从 E.purpurea 中，分离出了两种新的二元萜烯（variecolol 和 variecolin）以及三种新的黄色 2,3-二氰基-1,4-二苯基-1,3-丁二烯衍生物 epurpurins A-C，以及二元萜烯 variecolin（具有血管紧张素 II 结合抑制活性）。二氰化物衍生物对L1210细胞具有生长抑制活性。从 E.falconensis 和/或 E.fruticulosa 的菌丝体中分离出了六种新的氢化氮杂酮类化合物：falconensin E-G 和 I-N，以及两种具有长共轭体系的新色素 EF-Y1 和 EF-Y2。这些鹰嘴菌素预计具有对肿瘤促进剂的抑制活性。从E.heterothallica培养基中分离得到新的18,22-环甾醇，即艾甾醇B和C，以及艾甾醇A，其对烟曲霉具有较强的抗真菌活性。从E.foveolata早期培养液中分离得到一个新的表四硫二氧代哌嗪，secoemestrin C。从Talaromyces austrocalifornicus的子盘中分离得到氮杂菲酮和氢化蒽醌二聚体。还从 T.wortmanni 中分离出氢化阿扎菲酮衍生物和蒽醌二聚体 Skyrin。从 Petroomyces muricans 的子囊中，分离出四种新的双吲哚基苯衍生物：petromurin A-D、双吲哚基苯喹（asteriiquinone）、Pm-53 和吲哚二萜 petromindole。

项目成果

H.Takahashi, K.Nozawa, K.Kawai: "Isolation and Structures of Dicyanide Derivatives, Epurpurins A to C,from Emericella purpurea." Chem.Pharm.Bull. 44 (12). 2227-2230 (1996)

H.Takahashi、K.Nozawa、K.Kawai：“Emericella purpurea 中二氰化物衍生物 Epurpurins A 至 C 的分离和结构。”

T.Itabashi,N.Ogasawara,K.Nozawa,K.Kawai: "Isolation and Structures of New Azaphilone Derivatives,Falconensins E-G,from Emericella falconensis and Absolute Configuration of Ealconensins A-C" Chem.Pharm.Bull.44(12). 2213-2217 (1996)

T.Itabashi、N.Ogasawara、K.Nozawa、K.Kawai：“新 Azaphilone 衍生物 Falconensins E-G 的分离和结构，来自 Emericella falconensis 和 Ealconensins A-C 的绝对构型”Chem.Pharm.Bull.44(12)。

T.Itabashi, N.Ogasawara, K.Nozawa, K.Kawai: "Isolation and Structures of New Azaphilone Derivatives, Falconensins E-G,from Emericella falconensis and Absolute Configurations of Falconensins A-G" Chem.Pharm.Bull. 44 (12). 2213-2217 (1996)

T.Itabashi、N.Ogasawara、K.Nozawa、K.Kawai：“新 Azaphilone 衍生物 Falconensins E-G 的分离和结构，来自 Emericella falconensis 和 Falconensins A-G 的绝对构型”Chem.Pharm.Bull。

M.Ooike, K.Nozawa, S.Udagawa, K.Kawai: "Bisindolylbenzenoids from Petromyces muricatus" Can.J.Chem.(in press). (1997)

M.Ooike、K.Nozawa、S.Udakawa、K.Kawai：“来自 Petromyces muricatus 的 Bisindolylbenzenoids”Can.J.Chem.（印刷中）。

T.Itabashi,N.Ogasawara,K.Nozawa,K.Kawai: "Isolation and Structures of New Azaphilone Derivatives,Falconensins E-G,from Emericella falconensis and Absolute Configurations of Falconensins A-G" Chemical and Pharmaceutical Bulletin. 44. 2213-2217 (1996)

T.Itabashi、N.Ogasawara、K.Nozawa、K.Kawai：“新 Azaphilone 衍生物 Falconensins E-G 的分离和结构，来自 Emericella falconensis 和 Falconensins A-G 的绝对构型”化学和制药通报。