Cerebral blood flow velocity and serum fatty acid composition

脑血流速度和血清脂肪酸组成

• 批准号: 07680046
• 负责人: MARUYAMA Chizuko
• 金额: $ 1.47万
• 依托单位: Japan Wamen's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07680046/
• 关键词: fatty acids; cerebral atheroscrelosis; cerebral blood flow velocity; cerebral vessel diameter; cerebral circulatory resistance; fatty acids in diet; serum lipid concentrations; 頸動脈血流速; 頸動脈血管径; 頸動脈血管抵抗

The subjects consisted of 77men, 50-69years old, all of whom were inhabitants of Kiseicho in Mie prefecture. Blood samples were obtained after overnight fasting. Serum lipids were measured. Lipids were extracted by the method of Folch et al. and thin-layr chromatography on Silica gel was used to separate the lipid fractions. The fatty acids methyl esters in the phospholipid fractions were separated by gas-liquid chromatography. Cerebral atherosclerotic changes in the left carotid artery were measured noninvasively with an ultrasonic quantitative flow measurement system (QFM 2000XA,Hihon Koden Co., Ltd, Tokyo). Velocity, vessel diameter, Circulatory resistance in the region extending from the common cartid artery to the peripheral cerebral artery, was calculated. Food and beverage consumptions were recorded for one day before the day on which serum was obtained and were confirmed by an interview with a dietitian.Body mass index was 22.7(]SY+-[)2.8 (Mean(]SY+-[)SD), systolic and diastolic blood pressures were 127.2(]SY+-[)19.0mmHg and 81.4(]SY+-[)11.2mmHg, respectively. Velocity, diameter and Zo were 22.9(]SY+-[)5.3cm/sec, 7.26(]SY+-[)0.75mm and 10.1(]SY+-[)2.3mmHg・ml<@D1-1@>D1/sec, respectively. Amultiple regression function was devised to determine the significance of factors affecting Vel, in the best fitting linear regression equation expressing Vel, C18 : 0, C18 : 1, C20 : 5and C24 : 1 in the phospholipid fraction remained.

研究对象为77名男性，年龄50- 69岁，均为三重县纪成町居民。空腹过夜后采集血样。测定血脂。用Folch等人的方法提取脂质，并使用硅胶薄层色谱法分离脂质级分。磷脂组分中的脂肪酸甲酯通过气液色谱法分离。用超声定量流量测量系统（QFM 2000 XA，Hihon科登公司，Ltd，Tokyo）。计算颈总动脉至大脑周围动脉的血流速度、血管直径和循环阻力。体重指数为22.7 ± 2.8，收缩压和舒张压分别为127.2 ± 19.0mmHg和81.4 ± 11.2mmHg。流速、直径和Zo分别为22.9（SY ±）5.3cm/sec、7.26（SY ±）0.75mm和10.1（SY ±）2.3mmHg·ml<@D1-1@>D1/sec。用多元回归函数分析了影响Vel的因素，得到了Vel与剩余磷脂组分中的C18：0、C18：1、C20：5和C24：1的最佳线性回归方程。