Conformational Analysis and Molecular Design of Polypeptides for Creating Advanced Biomaterials

本文对胶原蛋白、弹性蛋白、bactenecin、γ-玉米醇溶蛋白等天然周期蛋白中存在的具有重复氨基酸序列的周期多肽进行了理论构象分析，并显示它们形成了新的有趣的螺旋构象，这些构象被认为与这些周期蛋白的分子功能有关。对合成的周期性多肽进行了实验分析，得到了支持理论结果的实验结果。此外，还尝试对α-螺旋、β-链和聚脯氨酸-II等二级结构构成的超二级结构进行理论构象分析。结果表明，从设计新的有用的角度来看，有许多具有有趣的结构特征的超二级结构。

Theoretical conformational analysis was tried for the periodic polypeptides having repetitive amino-acid sequences which are found in many native periodic proteins such as collagen, elastin, bactenecin, gamma-Zein, et al., and it was shown that they form new interesting helical conformations which are supposed to relate to the molecular functions of such periodic proteins. Experimental analysis was also tried for the synthetic periodic polypeptides, and experimental results supporting the theoretical results were obtained. Moreover, theoretical conformational analysis was tried for the super secondary structures constructed by the secondary structures such as alpha-helices, beta-strands, and polyproline-II structures. It was shown that there are many super secondary structures having interesting structural character from the viewpoints designing new useful.