Neural circuitry of maternal behaviour

母亲行为的神经回路

• 批准号: DP220101306
• 负责人: Prof Andrew Lawrence
• 金额: $ 29.4万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-04 至 2025-01-03
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101306
• 关键词: Neural; circuitry; maternal; behaviour

Elaborate maternal care is a defining characteristic of mammalian species, suggesting conserved brain pathways evolved to orchestrate these responses. The neural substrates underscoring maternal behaviour have not been fully elucidated. This project aims to investigate the brain circuitry underpinning maternal care using a multidisciplinary approach combining behavioural assays and pharmacogenetic manipulations in mice alongside sophisticated molecular and functional analyses. The outcomes of this project are expected to improve our understanding of how specific brain pathways govern maternal behaviour. The novel insight gained is expected to advance theories regarding the organisation of maternal care and enable their practical testing.

精心的母性护理是哺乳动物物种的一个决定性特征，这表明保守的大脑通路进化来协调这些反应。强调母性行为的神经基础尚未完全阐明。该项目旨在利用多学科方法，结合小鼠的行为测定和药物遗传学操作以及复杂的分子和功能分析，研究支持孕产妇护理的大脑回路。该项目的成果预计将提高我们对特定大脑通路如何控制母亲行为的理解。获得的新见解预计将推进有关孕产妇护理组织的理论并使其能够进行实际测试。