Alcohol and Striatal Adaptation

酒精和纹状体适应

• 批准号: nhmrc : 1120576
• 负责人: Prof Andrew Lawrence
• 金额: $ 66.53万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/alcohol-striatal-adaptation/946573
• 关键词: Alcohol; Striatal; Adaptation

In pilot studies, we have found that specific genes are modulated by long-term alcohol intake in a discrete part of the brain that drives habitual behaviours. We will now repeat these studies in post-mortem brain tissue from human alcoholics and age-matched controls. In addition, we will further characterise the functional consequences of long-term alcohol intake within this specific brain region and test new approaches to reduce the urge to consume alcohol.

在初步研究中，我们发现，特定的基因受到大脑中驱动习惯行为的离散部分长期饮酒的调节。我们现在将在人类酗酒者和年龄匹配的对照组的死后脑组织中重复这些研究。此外，我们还将进一步描述长期饮酒在这一特定大脑区域的功能后果，并测试减少饮酒冲动的新方法。