Cortictropin releasing factor as a therapeutic target for alcohol and drug abuse

促肾上腺皮质激素释放因子作为酒精和药物滥用的治疗靶点

• 批准号: nhmrc : 508976
• 负责人: Prof Andrew Lawrence
• 金额: $ 33.61万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cortictropin-releasing-factor-drug-abuse/82884
• 关键词: Cortictropin; releasing; factor; therapeutic; target

A key problem with alcoholism, as with addiction generally, is the chronically relapsing nature of the disorder. This can be modelled in rodents and there is good general correspondence between animal studies of reinstatement and human experience of relapse. We have identified brain chemicals involved in this process. Consequently, by better understanding the biological mechanisms related to addiction and relapse, we will be in a position to counter this devastating condition.

酒精中毒的一个关键问题，就像一般的成瘾问题一样，是这种疾病长期反复发作的本质。这可以在啮齿类动物身上建立模型，在动物恢复研究和人类复发经验之间有很好的总体对应关系。我们已经确定了参与这一过程的大脑化学物质。因此，通过更好地了解与成瘾和复发相关的生物学机制，我们将能够应对这种毁灭性的状况。