Elucidating the determinants of cation import across the kingdoms of life

阐明生命王国中阳离子输入的决定因素

• 批准号: DP220100713
• 负责人: Prof Christopher McDevitt
• 金额: $ 35.82万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-12-05 至 2025-12-05
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220100713
• 关键词: Elucidating; determinants; cation; import; across

The metal ion manganese is essential to all forms of life. This project aims to investigate how this poorly abundant cation is selectively acquired from the chemical complexity of the environment for import into cells by using state-of-the-art biochemical and microbiological techniques. This project expects to define the fundamental basis for how bacterial, archaeal and eukaryotic plastid cation-selective importers can discriminate manganese from chemical similar cations to achieve selective uptake. The expected outcomes of this work will be an understanding of the fundamental basis for selective metal import in biological systems. This should provide benefits for industry through synthetic biological applications of this knowledge.

金属离子锰对所有生命形式都是必不可少的。该项目旨在研究如何通过使用最先进的生物化学和微生物学技术，从环境的化学复杂性中选择性地获得这种丰度很低的阳离子，以便输入细胞。该项目旨在确定细菌，古细菌和真核质体阳离子选择性进口商如何将锰与化学类似阳离子区分开来以实现选择性吸收的基本基础。这项工作的预期成果将是在生物系统中的选择性金属进口的根本基础的理解。这将通过这一知识的合成生物应用为工业带来好处。