New molecular tools to study the mechanisms of bacterial metal homeostasis

研究细菌金属稳态机制的新分子工具

• 批准号: FT170100006
• 负责人: Prof Christopher McDevitt
• 金额: $ 61.61万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-12-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT170100006
• 关键词: New; molecular; tools; study; mechanisms

This project aims to provide new insight into how metal ion uptake is regulated. It will precisely measure the cellular concentrations of metal ions, reveal the roles of metal ions in essential cellular processes, and identify the molecular targets of metal toxicity. Metal ions are essential to all forms of life and are used by up to half of all proteins to facilitate cellular chemical processes. The intended outcome of the research is to provide new fundamental knowledge of the roles of metal ions in bacterial cells; knowledge that will be key to defining the chemical biology of living systems and will provide information essential to understanding how microbes adapt to changing environments.

该项目旨在为金属离子摄取如何被调节提供新的见解。它将精确测量细胞中金属离子的浓度，揭示金属离子在基本细胞过程中的作用，并确定金属毒性的分子靶点。金属离子对所有形式的生命都是必不可少的，多达一半的蛋白质都利用金属离子来促进细胞化学过程。这项研究的预期结果是为金属离子在细菌细胞中的作用提供新的基础知识；这些知识将是定义生命系统化学生物学的关键，并将为理解微生物如何适应不断变化的环境提供必要的信息。