慢性咳嗽の病態における下気道炎症の関与

下呼吸道炎症参与慢性咳嗽的病理学

• 批准号: 07770421
• 负责人: 新實 彰男
• 金额: $ 0.7万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Encouragement of Young Scientists (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07770421/
• 关键词: 慢性咳嗽; 咳喘息; 気道炎症; 好酸球; カプサイシン; 気管支肺胞洗浄; 気管支粘膜生検; 血清ECP値

1.喘鳴を伴う典型的喘息、咳嗽のみを訴える咳喘息、および非喘息性慢性咳嗽症例において、気管支肺胞洗浄(BAL)所見、気管支生検所見、血清ECP値を検討した。その結果、1)典型的喘息及び咳喘息では、BAL液の好酸球比率、気管支組織の好酸球数が健常対照群に比し有意に高値であった(典型的喘息と咳喘息の間には有意差なし)。非喘息性慢性咳嗽では、好酸球の比率・数は少なく対照群と差がなかったが、BAL液、組織のリンパ球増多を認めた。2)気道の好酸球性炎症を反映するとされる血清ECP値は、典型的喘息、咳喘息では対照群に比し有意に高値であった(典型的喘息、咳喘息の間には有意差なし)。非喘息性慢性咳嗽では健常者と有意差を認めなかった。3)気管支基底膜の厚さは、典型的喘息、咳喘息、非喘息性慢性咳嗽のいずれにおいても対照群に比し有意に増加していた。以上より、咳喘息では典型的喘息と同等の好酸球性炎症を認めること、非喘息性慢性咳嗽においても気道炎症が存在するが好酸球の関与は否定的であること、が示された。2.症状により3群に分類(喘鳴のみ、喘鳴と咳嗽、咳嗽のみ)した喘息患者と、非喘息性慢性咳嗽患者でカプサイシン咳受容体感受性を検討した。その結果、1)咳受容体感受性は、非喘息性慢性咳嗽患者では健常対照者に比し有意に亢進していたが、喘息の3群と健常者の比較、喘息の3群間での比較では有意差を認めなかった。2)喘息患者および全症例での検討で、カプサイシン咳受容体感受性とメサコリン気道過敏性の間に有意な相関を認めなかった。以上より、非喘息性慢性咳嗽患者ではカプサイシン咳受容体感受性が亢進していること、喘息患者ではその亢進は認めずまた喘息患者における咳嗽症状の発現には咳受容体感受性の関与は否定的であること、カプサイシン咳受容体感受性とメサコリン気道過敏性は独立して存在すること、が示された。

1. Wheezing with typical wheezing, coughing, wheezing, nonwheezing chronic cough, bronchoalveolar lavage (BAL), bronchoalveolar lavage (BAL), serum ECP. The results were as follows: 1) typical wheezing and wheezing wheezing, the ratio of good acid balls in BAL fluid, and the number of good acid balls in the tube group were higher than those in the control group (typical wheezing, wheezing and wheezing). The ratio of non-wheezing chronic cough and good acid globulin was lower than that of non-wheezing chronic cough, and the ratio of non-wheezing chronic cough and good acid globule was less than that of non-wheezing chronic cough, BAL fluid, tissue culture and so on. 2) Serum ECP levels, typical wheezing, wheezing and wheezing symptoms were significantly higher than those in healthy controls (typical wheezing, wheezing, wheezing and wheezing). Non-wheezing chronic cough "normal person" intentionally has a bad feeling. 3) bronchial basement membrane thickening, typical wheezing, wheezing, non-wheezing chronic cough, non-wheezing chronic cough. The above symptoms, cough and wheeze, typical wheezing, and non-wheezing chronic cough are similar to those of sour globular inflammation, non-wheezing chronic cough and non-wheezing chronic cough. two。 The symptoms were classified into three groups (wheezing, wheezing cough, coughing), wheezing patients and non-wheezing chronic cough patients. The results were as follows: 1) the patients with cough receptive somatosensory disorder and non-wheezing chronic cough were more likely to be hyperactive than those with normal wheezing, wheezing and wheezing 3 groups. 2) in patients with wheezing, there were cases of dyspnea, convulsion, anaphylaxis, dyspnea. In patients with chronic non-wheezing cough, patients with chronic non-wheezing cough, patients with chronic wheezing cough, patients with wheezing chronic cough, patients with chronic non-wheezing cough, patients with wheezing chronic cough, patients with wheezing, wheezing, whe Show me how to do it.